克罗恩病透壁愈合的研究现状

Research status of transmural healing in Crohn′s disease

克罗恩病是一种慢性透壁性炎症性疾病,其治疗目标一直是临床治疗、预后的重要观察点,因此,确定合适的治疗目标具有非常重要的临床价值。目前公认的长期治疗目标是内镜下黏膜愈合,但由于内镜检查存在局限性,通过横断面成像技术评价的透壁愈合被提出可能成为更好的治疗目标。国内对克罗恩病透壁愈合的认识及相关研究较少,本文将对国内外研究透壁愈合的文献进行综述,总结透壁愈合的现有定义及评估方法、临床意义、影响因素,以提高医务工作者对透壁愈合的了解,为克罗恩病确定治疗目标以及精准医疗提供依据。

Crohn′s disease is a chronic transmural inflammatory disease,whose therapeutic target has always been an important observation point for clinical treatment and prognosis.Therefore,determining the appropriate therapeutic target is key to clinicians.At present,the recognized long-term treatment target is endoscopic mucosal healing.However,due to the limitations of endoscopy,transmural healing evaluated by cross-sectional imaging technology has been proposed as a better treatment target.Understanding of transmural healing in Crohn′s disease and related reviews are few in China.In this review,literature on transmural healing at home and abroad will be reviewed to summarize the existing definition,evaluation methods,clinical significance and influencing factors of transmural healing,so as to improve the understanding of clinicians on transmural healing and provide basis for determining treatment targets and precision medicine for Crohn′s disease.