超脉冲CO_(2)点阵激光联合硅凝胶治疗烧伤后增生性瘢痕的临床疗效

Clinical efficacy of ultra-pulsed fractional CO_(2) laser combined with fusidic acid cream in the treatment of hypertrophic scar after burn

目的探讨超脉冲CO_(2)点阵激光联合硅凝胶治疗烧伤后增生性瘢痕的临床疗效。方法选择2023年4月至2024年4月郑州大学附属洛阳中心医院收治的98例增生性瘢痕患者为研究对象,根据治疗方法不同分成对照组与观察组,每组49例。对照组患者予超脉冲CO_(2)点阵激光治疗;观察组患者予超脉冲CO_(2)点阵激光治疗,并使用硅凝胶涂抹。两组患者观察24周。比较两组患者的疼痛视觉模拟评分法(visual analogue scales,VAS)评分、临床疗效以及烧伤后增生性瘢痕相关指标。结果治疗后,观察组患者VAS评分低于对照组,差异有统计学意义(P<0.05);观察组患者的总有效率93.88%,高于对照组75.51%,差异有统计学意义(P<0.05)。治疗后,观察组患者的温哥华瘢痕量表、观察者瘢痕评估量表、患者瘢痕评估量表评分低于对照组,差异均有统计学意义(P<0.05)。结论超脉冲CO_(2)点阵激光联合硅凝胶治疗烧伤后增生性瘢痕的效果显著,能减轻患者的疼痛,改善烧伤后增生性瘢痕相关症状。

Objective To investigate the clinical efficacy of ultra-pulsed fractional CO_(2) laser combined with fusidic acid cream in the treatment of hypertrophic scar after burn.Methods Ninety-eight patients with hypertrophic scars admitted to Luoyang Central Hospital affiliated to Zhengzhou University from April 2023 to April 2024 were selected as the research subjects.They were divided into a control group and an observation group according to different treatment methods,with 49 cases in each group.The control group patients were treated with superpulse CO_(2) fractional laser;The patients in the observation group were treated with CO_(2) dot matrix laser and the patients in the control group were smeared with silicon gel.Two groups of patients were observed for 24 weeks.Compare the visual analogue scales(VAS)scores for pain,clinical efficacy,and post burn hypertrophic scar related indicators between two groups of patients.Results After treatment,the VAS scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05);The total effective rate of the observation group patients was 93.88%,which was higher than the control group's 75.51%,and the difference was statistically significant(P<0.05).After treatment,the Vancouver Scar Scale,Observer Scar Assessment Scale,and Patient Scar Assessment Scale scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusions The clinical efficacy of Ultra-pulsed Fractional CO_(2) laser combined with fusidic acid cream in the treatment of hypertrophic scar after burn is evident,can relieve the pain of patients,and improve the symptoms related to hypertrophic scar after burns.