二肽基肽酶-4抑制剂在缺血性卒中预防和治疗中的作用

Role of dipeptidyl peptidase-4 inhibitors in the prevention and treatment of ischemic stroke

糖尿病是缺血性卒中的重要危险因素,而缺血性卒中后的应激性高血糖会加剧缺血性脑损伤。二肽基肽酶-4(dipeptidyl peptidase-4,DPP-4)抑制剂作为近年来新开发的降糖药,成为2型糖尿病治疗药物的重要研究方向之一。虽然现有的临床试验数据尚未明确证实DPP-4抑制剂在预防糖尿病患者缺血性卒中方面的有效性,但动物模型研究显示DPP-4抑制剂能通过抗炎、抗凋亡以及促进神经发生和血管新生等机制,在缺血性脑损伤过程中发挥保护作用。文章综述了DPP-4抑制剂在缺血性卒中预防和治疗中的作用及其可能机制。

Diabetes is an important risk factor for ischemic stroke,and stress hyperglycemia after ischemic stroke will aggravate ischemic brain damage.Dipeptidyl peptidase-4(DPP-4)inhibitors,as newly developed hypoglycemic drugs in recent years,have become one of the important research directions of type 2 diabetes drugs.Although the existing clinical trial data have not clearly confirmed the effectiveness of DPP-4 inhibitors in preventing ischemic stroke in patients with diabetes,animal model studies have shown that DPP-4 inhibitors can exert protective effects during ischemic brain injury through mechanisms such as anti-inflammatory,anti-apoptotic and promoting neurogenesis and angiogenesis.This article reviews the role and possible mechanisms of DPP-4 inhibitors in the prevention and treatment of ischemic stroke.