脑白质高信号半暗带

White matter hyperintensity penumbra

白质高信号(white matter hyperintensities,WMHs)是脑小血管病(cerebral small vessel disease,CSVD)的主要影像学标志物之一。随着神经影像学技术的发展,WMHs半暗带(WMHs penumbra,WMH-P)逐渐成为研究热点。WMH-P是指WMHs病灶周围存在的脑组织微结构完整性破坏或血流灌注降低的区域,在常规MRI序列上不可见。其不仅是WMH进展的危险因素,还与CSVD患者的认知障碍、步态异常等临床症状相关,被认为是一个潜在可逆转的治疗新靶点。

White matter hyperintensities(WMHs)are one of the main imaging biomarkers of cerebral small vessel disease(CSVD).With the development of neuroimaging technology,the WMH penumbra(WMH-P)has gradually become a research hotspot.WMH-P refers to the area of brain tissue microstructural integrity destruction or reduced blood flow perfusion around WMH lesions,which is not visible on conventional MRI sequences.It is not only a risk factor for the progression of WMHs,but also associated with clinical symptoms such as cognitive impairment and gait abnormalities in patients with CSVD,and is considered a new potential and reversible therapeutic target.