无创呼吸机的不同应用模式对肺炎合并呼吸衰竭的治疗效果的对比研究

Comparative Study on the Effect of Different Application Modes of Noninvasive Ventilator on Pneumonia Complicated with Respiratory Failure

目的 对比研究无创呼吸机不同应用模式治疗肺炎合并呼吸衰竭的效果。方法 回顾性收集2020年6月-2023年10月在本院进行治疗的105例肺炎合并呼吸衰竭患者的临床资料。根据无创呼吸机应用模式的不同将患者分为对照组[自主呼吸和时间控制(ST)模式,n=51]和观察组[平均容积保证压力支持(AVAPS)模式,n=54]。分析对比两组的通气情况[二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))、动脉血氧饱和度(oxygen saturation,SaO_(2))及血氧分压(partial pressure of oxygen,Pa O_(2))]、肺功能[第一秒用力肺活量(forced vital capacity in the first second,FEV1)、最大肺活量(forced vital capacity,FVC)、1秒率(FEV1/FVC)]及不良反应。结果 治疗后,两组PaO_(2)、SaO_(2)水平均显著上升,PaCO_(2)水平均显著下降,且观察组的变化幅度显著大于对照组(P<0.05)。治疗后,两组的FEV1、FVC、FEV1/FVC各项肺功能指标均显著高于治疗前,且观察组的各项肺功能指标均显著高于对照组(P<0.05)。观察组不良反应总发生率显著低于对照组(P<0.05)。结论 在肺炎合并呼吸衰竭患者中予以无创呼吸机的AVAPS模式,相比ST模式的治疗效果更佳,能有效改善患者通气功能,提升肺功能,且安全性更高。

Objective To compare the effect of different application modes of noninvasive ventilator in the treatment of pneumonia complicated with respiratory failure.Methods The clinical data of 105 patients with pneumonia combined with respiratory failure treated in our hospital from June 2020 to October 2023 were retrospectively collected.Patients were divided into control group(spontaneous breathing and time control(ST)mode,n=51)and observation group(Mean volume assured Pressure support(AVAPS)mode,n=54)according to different modes of non-invasive ventilator application.The Ventilation condition[a arterial Partial Pressure of Carbon Dioxide(PaCO_(2)),Oxygen Saturation(SaO_(2)),partial pressure of oxygen(PaO_(2))]pulmonary function[Forced vital capacity in the first second(FEV1),Forced vital capacity(FVC),one-second rate(FEV1/FVC)],and adverse reactions were analyzed and compared between the two groups.Results After treatment,PaO_(2) and SaO_(2) levels were significantly increased,and PaCO_(2) levels were significantly decreased in both groups,and the change range of observation group was significantly greater than that of control group(P<0.05).After treatment,the pulmonary function indexes of FEV1,FVC and FEV1/FVC in both groups were significantly higher than before treatment,and the pulmonary function indexes in observation group were significantly higher than those in control group(P<0.05).The total incidence of adverse reactions in observation group was significantly lower than that in control group(P<0.05).Conclusion In patients with pneumonia complicated with respiratory failure,AVAPS mode of non-invasive ventilator has better therapeutic effect than ST mode,which can effectively improve the ventilation function and lung function of patients,and has higher safety.