残余胆固醇水平与急性冠脉综合征患者SYNTAX评分的相关性研究

The Correlation Between Residual Cholesterol Levels and SYNTAX Score in Patients with Acute Coronary Syndrome

目的 探讨残余胆固醇(RC)水平与急性冠脉综合征(ACS)患者SYNTAX评分的相关性。方法 选取2022年6月至2023年4月医院收治的85例ACS患者,评估所有患者的SYNTAX评分,根据结果分为高危组(SYNTAX评分≥33分)、中危组(SYNTAX评分在23~32分)、低危组(SYNTAX评分在0~22分),设计基线资料调查表,详细统计3组患者的基线资料并比较,重点分析RC水平与ACS患者SYNTAX评分的相关性。结果 85例ACS患者经SYNTAX评分在0~22分的有43例,纳入低危组,SYNTAX评分在23~32分的有25例,纳入中危组,SYNTAX评分在33分及以上的有17例,纳入高危组;高危组患者的血清RC水平依次高于中危组、低危组(P<0.05),3组患者的吸烟史、临床表现、合并糖尿病、高密度脂蛋白胆固醇(HDL-Ch)、年龄、性别、合并高血压、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-Ch)水平比较,无统计学差异(P>0.05);经相关性分析(Kendall's tau-b)发现,RC与ACS患者SYNTAX评分呈正相关(r>0,P<0.05)。结论 ACS患者的RC水平异常表达与SYNTAX评分密切相关,且水平过表达,提示冠脉病变严重。

Objective To investigate the correlation between residual cholesterol(RC)levels and SYNTAX scores in patients with acute coronary syndrome(ACS).Methods 85 ACS patients admitted to the hospital from June 2022 to April 2023 were selected and their SYNTAX scores were evaluated.Based on the results,they were divided into high-risk group(SYNTAX score≥33 points),medium risk group(SYNTAX score between 23-32 points),and low risk group(SYNTAX score between 0-22 points).A baseline data questionnaire was designed to collect detailed baseline data of the three groups of patients and compare them,with a focus on analyzing the correlation between RC levels and SYNTAX scores of ACS patients.Results Among the 85 ACS patients,43 had a SYNTAX score of 0-22 and were included in the low-risk group.25 had a SYNTAX score of 23-32 and were included in the medium risk group.17 had a SYNTAX score of≥33 and were included in the high-risk group;The serum RC levels of the high-risk group were higher than those of the moderate risk group and the low-risk group in turn(P<0.05).There was no statistical difference in the smoking history,clinical manifestations,diabetes,high-density lipoprotein cholesterol(HDL-Ch),age,sex,hypertension,total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-Ch)levels among the three groups(P>0.05);After correlation analysis(Kendall's tau-b),it was found that RC was positively correlated with SYNTAX score in ACS patients(r>0,P<0.05).Conclusion The abnormal expression of RC levels in ACS patients is closely related to SYNTAX score,and overexpression of RC levels suggests severe coronary artery disease.