血清TSP-1、VEGF、SPA及SPD联合检测在早发型重度子痫前期诊断中应用价值

The Value of Combined Detection of Serum TSP-1,VEGF,SPA,and SPD in the Diagnosis of Early-onset Severe Preeclampsia

目的 分析血小板反应蛋白1(TSP-1)、血管内皮生长因子(VEGF)、表面活性蛋白A(SPA)、表面活性蛋白D(SPD)联合检测诊断早发型重度子痫前期(EOSP)的效能。方法 92例EOSP孕妇,均于2021年4月-2022年4月被本院收治,将其划入观察组,健康孕妇87例,同期于本院行健康体检,将其划入对照组,比较两组TSP-1、VEGF、SPA及SPD差异;并描绘受试者工作曲线(ROC),分析TSP-1、VEGF、SPA、SPD联合诊断EOSP的具体效果。结果 观察组TSP-1为(3.08±0.47)ng/m L,高于对照组的(1.79±0.23)ng/m L,VEGF为(298.36±28.44)pg/m L、SPA为(13.30±2.06)ng/m L、SPD为(8.63±1.59)ng/m L,低于对照组的(335.49±33.67)pg/m L、(23.59±3.41)ng/m L、(19.20±2.36)ng/m L,有统计学差异(P<0.05);ROC结果显示,TSP-1、VEGF、SPA、SPD联合检测诊断EOSP的曲线下面积(AUC)为0.908(95%CI:0.867-0.949),高于TSP-1单独检测的0.833(95%CI:0.770-0.896)、VEGF单独检测的0.797(95%CI:0.733-0.861)、SPA单独检测的0.804(95%CI:0.732-0.876)、SPD单独检测的0.813(95%CI:0.743-0.884)。结论 TSP-1、VEGF、SPA、SPD在EOSP孕妇机体内呈异常表达,TSP-1、VEGF、SPA、SPD四者联合检测能够提高EOSP的诊断效果,可为临床提供有效的参考依据,临床应用价值较高。

Objective To analyze the efficacy of combined detection of platelet reactive protein 1(TSP-1),Vascular endothelial growth factor(VEGF),surfactant protein A(SPA)and surfactant protein D(SPD)in the diagnosis of early onset severe preeclampsia(EOSP).Methods 92 pregnant women with EOSP were admitted to our hospital from April 2021 to April 2022 and were included in the observation group.87 healthy pregnant women underwent health examinations at our hospital during the same period and were included in the control group.The differences in TSP-1,VEGF,SPA,and SPD between the two groups were compared;And depict the receiver operating characteristic(ROC)curve,analyze the specific effect of TSP-1,VEGF,SPA,SPD combined diagnosis of EOSP.Results The results showed that the TSP-1 of the observation group was(3.08±0.47)ng/mL,which was higher than the control group's(1.79±0.23)ng/mL,VEGF was(298.36±28.44)pg/mL,SPA was(13.30±2.06)ng/mL,and SPD was(8.63±1.59)ng/mL,which was lower than the control group's(335.49±33.67)pg/mL,(23.59±3.41)ng/mL,and(19.20±2.36)ng/mL,with statistical differences(P<0.05);the ROC results showed that the area under the curve(AUC)of TSP-1,VEGF,SPA,and SPD combined detection for diagnosing EOSP was 0.908(95%CI:0.867-0.949),which was higher than that of TSP-1 alone detected by 0.833(95%CI:0.770-0.896),VEGF alone detected by 0.797(95%CI:0.733-0.861),SPA alone detected by 0.804(95%CI:0.732-0.876),and SPD alone detected by 0.813(95%CI:0.743-0.884).Conclusion TSP-1,VEGF,SPA,and SPD are abnormally expressed in the body of EOSP pregnant women.The combined detection of TSP-1,VEGF,SPA,and SPD can improve the diagnostic effect of EOSP and provide effective reference for clinical practice.The clinical application value is high.