达格列净联合系统康复运动对2型糖尿病的效果及对血脂、体重的影响

Effect of Dapagliflozin Combined with Systematic Rehabilitation Exercise on Type 2 Diabetes Mellitus and Effect on Blood Lipid and Body Weight

目的 探讨达格列净联合系统康复运动对2型糖尿病(T2DM)的治疗效果及对血脂、体重的影响。方法 选取我院2020年10月-2022年6月收治的88例2型糖尿病患者,随机分为对照组及研究组,各44例。对照组采用达格列净治疗,研究组在对照组的基础上联合系统化康复运动训练,3个月为一个观察期,比较两组疗效、血脂代谢、体重变化。结果 治疗后,两组FBG、2h PG水平均低于治疗前(P<0.05),但组间比较无差异(P>0.05)。治疗后,两组HOMA-IR降低,C肽、HOMA-β升高,但组间比较无差异(P>0.05)。治疗后,两组TC、TG、LDL-C降低,HDL-C升高,而研究组改善优于对照组(P<0.05)。对照组治疗前后腹围、BMI指数无明显变化(P>0.05),研究组治疗后低于治疗前(P<0.05)。结论 达格列净联合系统康复运动不仅能够改善2型糖尿病患者血糖及胰岛素功能,而且又助于改善血脂代谢,降低患者腹围及体重,更利于血糖的控制。

Objective To investigate the therapeutic effect of dapagliflozin combined with systemic rehabilitation exercise on type 2 diabetes mellitus(T2DM)and its effect on blood lipids and body weight.Methods A total of 88 patients with type 2 diabetes admitted to our hospital from October 2020 to June 2022 were randomly divided into control group and research group,with 44 cases each.The control group was treated with dapagliflozin,and the study group combined with systematic rehabilitation exercise training on the basis of the control group,with a 3-month observation period,compared the efficacy of the two groups[fasting blood glucose(FBG),postprandial 2h blood glucose(2hPG),insulin resistance index(HOMA-IR),C peptide,βcell function index(HOMA-β)as the main indicators],blood lipid metabolism[mainly based on total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),High-density lipoprotein cholesterol(HDL-C)as the main indicators],weight[mainly based on body mass index(BMI),abdominal circumference as the main indicators].Results After treatment,the levels of FBG and 2hPG in both groups were lower than those before treatment(P<0.05),but there was no significant comparison between groups(P>0.05).After treatment,HOMA-IR decreased,and C peptide and HOMA-βincreased,but there was no significant comparison between the groups(P>0.05).After treatment,TC,TG,LDL-C decreased and HDL-C increased between the two groups,while the improvement in the study group was better than that in the control group,and the difference between the two groups was statistically significant(P<0.05).There was no significant change in abdominal circumference and BMI index before and after treatment(P>0.05)in the control group,and the difference was statistically significant(P<0.05)after treatment compared with before treatment.Conclusion Dapagliflozin combined with systematic rehabilitation exercise can not only improve blood glucose and insulin function in patients with type 2 diabetes,but also help improve blood lipid metabolism,reduce abdominal circumference and body weight,and be more conducive to blood glucose control.