血清IgE、IL-6水平在哮喘慢阻肺重叠患者中的变化及与肺功能的关系

Changes of serum IgE and IL-6 levels in patients with asthma COPD overlap syndrome and their relationship with lung function

目的:探讨血清IgE、IL-6水平在哮喘慢阻肺重叠患者中的变化及其与肺功能的关系。方法:选取2022年10月-2023年10月期间在本院住院治疗的哮喘慢阻肺重叠患者34例为研究组。选择同时期治疗的慢阻肺患者50例为对照1组,同时期治疗的哮喘患者50例为对照2组。收集患者基本资料,分别测定三组IgE、IL-6水平,检查肺功能。对数据进行比较处理。结果:三组患者基础资料比较差异无统计学意义(P>0.05)。研究组IgE、IL-6水平高于对照1组、对照2组,差异显著(P<0.05),对照1组、对照2组间IgE、IL-6水平比较差异不显著(P>0.05);FVC、FEV比较,研究组显著低于对照1组、对照2组,差异显著(P<0.05),对照1组、对照2组间IgE、IL-6水平比较差异不显著(P>0.05)。稳定期患者较急性发作期各项指标均好转,IgE、IL-6水平降低,差异显著(P<0.05),肺功能指标升高,差异显著(P<0.05)。结论:哮喘慢阻肺重叠患者较血清IgE、IL-6水平显著升高,反映肺功能较差,病情稳定后指标显著回落,肺功能好转。对IgE、IL-6水平的监测可以为临床病情监测提供依据,指导诊断和治疗。

Objective:To investigate the changes of serum IgE and IL-6 levels in patients with chronic obstructive pulmonary disease(COPD)overlapping bronchial asthma and their relationship with lung function.Methods:A total of 34 patients with COPD overlap who were hospitalized in our hospital from October 2022 to October 2023 were selected as the study group.Fifty COPD patients treated in the same period were selected as control group 1,and 50 bronchial asthma patients treated in the same period were selected as control group 2.The basic data of the patients were collected,IgE and IL-6 levels were measured respectively,and lung function was examined.Compare and process the data.Results:There was no significant difference in basic data among the three groups(P>0.05).IgE and IL-6 levels in study group were higher than those in control group 1 and control group 2,the difference was significant(P<0.05),but there was no significant diference between control group 1 and control group 2(P≥0.05).Compared with FVC and FEV,the study group was significantly lower than control group 1 and control group 2,the difference was significant(P<0.05),but the IgE and IL-6 levels between control group 1 and control group 2 were not significantly different(P>0.05).Compared with acute stage,all indexes were improved in stable stage,IgE and IL-6 levels were decreased,the difference was significant(P<0.05),and lung function indexes were increased,the difference was significant(P<0.05).Conclusion:The serum IgE and IL-6 levels in patients with COPD overlap of asthma were significantly higher than those in patients with COPD overlap,reflecting poor lung function.The monitoring of IgE and IL-6 levels can provide evidence for clinical disease monitoring and guide diagnosis and treatment.