超声C-TIRADS联合血清miR-107检测对甲状腺结节性质的诊断价值

Diagnostic value of ultrasound C-TIRADS combined with serum mir-107 in detection of thyroid nodules

目的探讨超声甲状腺影像报告和数据系统(C-TIRADS)联合血清微小RNA-107(miR-107)检测对甲状腺结节性质的诊断价值。方法选取2022年4月至2024年1月新疆医科大学附属肿瘤医院患甲状腺结节的患者98例(共113个结节)作为研究对象,均进行C-TIRADS分类,并检测血清miR-107水平。根据手术病理是否出现恶性结节分恶性组、良性组。分析超声C-TIRADS分类、血清miR-107水平与甲状腺结节良恶性的关系及其对甲状腺结节的诊断价值,并进行校准曲线分析。结果98例甲状腺结节患者(113个结节)中有83个良性结节,包括结节性甲状腺肿49个、甲状腺腺瘤24个、桥本甲状腺炎10个,其余30个恶性结节均为甲状腺乳头状癌。恶性结节均位于包膜下,结节内部钙化,C-TIRADS分类为4b或4c。恶性组患者血清miR-107水平高于良性组(P<0.05)。行Logistic多因素回归分析结果显示结节位置位于包膜下、结节内部钙化、C-TIRADS分类为4b或4c、miR-107是恶性甲状腺结节的独立危险因素(P<0.05)。超声C-TIRADS联合血清miR-107水平诊断甲状腺结节性质的曲线下面积(AUC)值为0.907,大于二者单独诊断甲状腺结节性质的AUC值(0.702和0.835)(Z=3.300,P=0.001;Z=2.410,P=0.016)。超声C-TIRADS联合血清miR-107水平诊断甲状腺结节性质的预测值与真实值一致性较好,Brier得分为0.114,校准斜率为0.809,校准度良好。结论超声C-TIRADS联合血清miR-107水平在诊断甲状腺结节性质方面具有较高临床应用价值。

Objective To investigate the diagnostic value of thyroid nodules by C-TIRADS combined with serum micrornA-107(miR-107)detection.Methods Ninety-eight patients with thyroid nodules(113 nodules)in Xinjiang Medical University Affiliated Cancer Hospital from April 2022 to January 2024 were selected as the study objects,all of which were classified by C-TIRADS and serum miR-107 levels were detected.According to surgical pathology,malignant nodules were divided into malignant group and benign group.The relationship between ultrasonic C-TIRADS classification and serum miR-107 level and benign and malignant thyroid nodules were analyzed,and the diagnostic value of thyroid nodules was analyzed.Results There were 113 nodules in 98 patients with thyroid nodules,of which 83 were benign,including 49 nodular goiter,24 thyroid adenomas,10 Hashimoto thyroiditis,and the remaining 30 malignant nodules were papillary carcinoma of thyroid.The nodules in the malignant group were subcapsular,the nodules were calcified inside,the C-TIRADS were classified as 4b or 4c and miR-107 were more than those in the benign group(P<0.05).Subcapsular nodules,intracranial calcification,C-TIRADS classification as 4b or 4c,and miR-107 were independent risk factors for malignant thyroid nodules(P<0.05).The AUC value of ultrasound C-TIRADS combined with serum miR-107 level in the diagnosis of thyroid nodule properties was 0.907,which was higher than the AUC value of 0.702 and 0.835 respectively(Z statistics/P=3.300/0.001,2.410/0.016).The predicted value of thyroid nodule properties in the diagnosis of ultrasonic C-TIRADS combined with serum miR-107 level was in good agreement with the real value,the Brier score was 0.114,the calibration slope was 0.809,and the calibration degree was good.Conclusion Ultrasound C-TIRADS combined with serum miR-107 level has high clinical application value in the diagnosis of thyroid nodule properties.