摘要
细菌耐药性已经非常严峻,防治耐药细菌感染是当下亟须解决的紧迫问题。噬菌体可用于防治耐药细菌感染,如果能更广泛地被用于临床,将会造福更多患者。噬菌体疗法目前仍面临一定挑战。从法律法规伦理、社会接受度、背景明确的噬菌体资源缺乏、制剂制备标准化和质量评估与个体化治疗方案定制五个方面入手,基于国内外噬菌体的临床治疗和研究现状,综合归纳了噬菌体在治疗耐药细菌感染方面所遇到的困难和现有解决方法。
In recent years,bacteria resistance has become a serious problem,and there is an urgent need to find solutions to prevent and treat infections caused by these bacteria.Phages can be used to prevent and treat drug-resistant bacteria,and many patients would benefit if they are successful in the clinic.However,challenges remain.This article reviews them from five aspects:laws and regulations,social acceptance,standardized therapeutic phage preparations and their quality evaluation,lack of enough phages with clear background,and customization of personalized treatment plans.Based on the clinical treatment and recent research on phage in China and the rest of the world,we comprehensively summarize the limitations encountered by phage therapy entering the clinic and their solutions.
作者
何静怡
崔泽林
HE Jingyi;CUI Zelin(Department of Laboratory Medicine,Shanghai General Hospital,Shanghai 201620,China;College of Health Science and Technology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2024年第8期142-147,共6页
China Biotechnology
基金
国家自然科学基金(81872540)
上海市浦江人才计划(22PJD059)
2023年上海市“医苑新星”青年医学人才类-临床检验项目资助项目。
关键词
噬菌体治疗
抗菌
细菌耐药
Phage therapy
Antibacterial
Bacterial resistance
