间歇光疗联合双歧杆菌三联活菌胶囊治疗新生儿高胆红素血症的效果

Effect analysis of intermittent phototherapy combined with bifidobacterium triple live capsule on neonatal hyperbilirubinemia

目的:探讨间歇光疗联合双歧杆菌三联活菌胶囊对新生儿高胆红素血症的效果。方法:选取120例高胆红素血症患儿为研究对象,依据治疗方式不同分为对照组和研究组,每组各60例。对照组患儿给予常规光疗治疗;研究组患儿给予间歇光疗联合双歧杆菌三联活菌胶囊治疗,均治疗至患儿健康出院。比较两组患儿临床疗效、治疗后各个时段总胆红素(TBil)水平、治疗后生化指标[C反应蛋白(CRP)、白细胞介素6(IL-6)、天冬氨酸氨基酸转移酶(AST)、丙氨酸氨基转移酶(ALT)水平]及并发症发生情况。结果:研究组患儿治疗总有效率高于对照组(98.33%vs.86.67%,P<0.05)。治疗后3、7 d,两组患儿总胆红素(TBil)水平均随时间延长逐渐降低(P<0.05),且研究组各时段均低于对照组(P<0.05)。治疗后,研究组患儿血清CRP、IL-6、AST、ALT水平均低于对照组(P<0.05);并发症总发生率低于对照组(5.00%vs.18.33%,P<0.05)。结论:新生儿高胆红素血症应用间歇光疗联合双歧杆菌三联活菌胶囊治疗能缩短康复进程,消除临床症状,改善生化指标,减少并发症发生率,值得临床推广。

Objective:To investigate the efficacy of intermittent phototherapy in combination with bifidobacterium triple live capsule as a treatment for neonatal hyperbilirubinemia.Methods:A total of 120 children diagnosed with hyperbilirubinemia were selected for this study.They were divided into two groups according to different treatment methods:a control group(n=60)receiving conventional phototherapy,and a study group(n=60)receiving intermittent phototherapy combined with bifidobacterium triple live capsule.The total effective rate,levels of total bilirubin(TBil)before and after treatment,changes in biochemical indexes[C-reactive protein(CRP),interleukin-6(IL-6),aspartate amino acid transferasee(AST),alanine aminotransferase(ALT)levels],and incidence of complications before and after treatment were compared between the two groups.Results:The total effective rates in the study group was higher than that in the control group(98.33%vs.86.67%,P<0.05).The levels of TBil in both groups gradually decreased over time at day 3 and day 7 after treatment,with the study group consistently exhibiting lower TBil levels than the control group at all time points post-treatment(P<0.05).Following treatment,the study group showed lower levels of serum CRP,IL-6,AST,and ALT compared to the control group(P<0.05).The complication rate in the study group was lower than that in the control group(5.00%vs.18.33%,P<0.05).Conclusion:The treatment of neonatal hyperbilirubinemia with intermittent phototherapy combined with bifidobacterium triple live capsule not only accelerates the rehabilitation process,alleviates clinical symptoms,improves biochemical markers,reduces the incidence of complications,which is worthy of clinical promotion.