异体异种器官移植的研究进展

Advancements in xenotransplantation research

近年来,器官移植技术得到了迅猛发展并广泛应用,尽管如此,供体器官短缺依然是制约器官移植发展的主要挑战,而随着异种器官移植技术的提升则可能是解决这一难题的有效途径。然而,免疫排斥、凝血紊乱、炎症反应、感染风险和免疫抑制策略等,仍是需要克服的关键问题。本文综述异体器官移植的最新研究进展,包括免疫学机制、移植并发症和新技术等方面,以全面概述该领域的发展,并重点关注异体器官移植中异种排斥、异种感染、生理功能,旨在为推动异体器官移植的临床应用和未来发展提供参考和展望。

In recent years,organ transplantation technology has developed rapidly and has been widely applied.Despite this progress,the shortage of donor organs remains a major challenge that restricts the development of organ transplantation.The advancement of xenotransplantation technology may offer an effective solution to this problem.However,key issues such as immune rejection,coagulation disorders,inflammatory responses,infection risks,and immunosuppressive strategies still need to be addressed.This article reviews the latest research progress in xenotransplantation,including immunological mechanisms,transplant complications,and new technologies,to provide a comprehensive overview of the development in this field.It focuses on xenogeneic rejection,xenozoonosis,and physiological function in xenotransplantation,aiming to offer references and perspectives for promoting the clinical practice and future development of xenotransplantation.