RNA表观遗传修饰与免疫细胞功能调控

RNA epigenetic modification and regulation of immune cells function

RNA的表观遗传修饰是一种发生在RNA分子的化学修饰,在不改变DNA序列的情况下,它能够导致基因表达发生可遗传的改变。在天然免疫应答和适应性免疫应答中,RNA的表观遗传修饰通过影响RNA的稳定性、剪接、折叠、输出、运输和蛋白质翻译效率进而调控基因的表达,最终在免疫细胞的分化、成熟、应答反应方面发挥重要作用。本文就几种常见的RNA表观遗传修饰类型的生物学调控过程及其在多种免疫细胞中的功能和机制的研究进展作一综述。

RNA epigenetic modification is a type of chemical modification that always occurs on RNA molecules,and it can lead to inheritable changes in gene expression without altering the DNA sequence.In both the innate and adaptive immune responses,RNA epigenetic modification regulates gene expression by affecting RNA stability,splicing,folding,export,transport,and protein translation efficiency,which ultimately plays a critical role in immune cell differentiation,maturation,and response.This paper provides a comprehensive review of the biological regulatory processes of several common types of RNA epigenetic modification,as well as the research progress on their functions and mechanisms in various immune cells.