脓毒症患者中肺炎克雷伯菌的分布及耐药情况研究

Study on Distribution and Drug Resistance of Klebsiella Pneumoniae in Patients with Sepsis

目的:探讨在耐药肺炎克雷伯菌脓毒症患者中肺炎克雷伯菌的分布及耐药情况.方法:选取2022年1月至2023年7月期间本院收治的80例脓毒症患者为研究对象,患者均予以实验室相关指标检测,分析其病原菌分布与构成情况.结果:80例脓毒症患者合计有190株病原体,其中革兰阴性菌株最多,肺炎克雷伯菌占12.63%,并且药敏试验结果显示肺炎克雷伯菌仅对头孢唑林、头孢呋辛、头孢他啶、头孢曲松、氨曲南这5种药物的耐药率超过45%.结论:对于脓毒症患者,诊疗过程中应该重视实验室微生物检测数据,加强耐药肺炎克雷伯菌耐药状况监控,可以更好地进行针对性治疗以及预后评估.

Objective:To explore the distribution and drug resistance of Klebsiella pneumoniae in patients with sepsis.Methods:A total of 80 patients with sepsis admitted to our hospital from January 2022 to July 2023 were selected as the research objects,and all of them were tested with relevant laboratory indicators to analyze the distribution and composition of pathogenic bacteria.Results:There were 190 strains of pathogens in the 80 patients with sepsis,among which gram-negative strains were the most common,while Klebsiella pneumoniae accounted for 12.63%,and the drug susceptibility test results showed that the resistance rate of Klebsiella pneumoniae to five drugs:cefazolin,cefuroxime,ceftazidme,ceftriaxone and amtronam was over 45%.Conclusion:For sepsis patients,paying attention to laboratory microbial detection and strengthening monitoring drug resistance of resistant Klebsiella pneumoniae during diagnosis and treatment can effectively control the development of patients'disease.