转录因子7-like 2在宫颈癌中表达水平及其与顺铂化疗敏感性关系研究

Expression level of transcription factor 7-like 2 in cervical cancer and its relationship with cisplatin chemotherapy sensitivity

目的:探究转录因子7-like 2(TCF7L2)在宫颈癌患者中表达水平及其与顺铂化疗敏感性的相关性。方法:收集68例宫颈癌患者(观察组)和68例体检正常者(对照组)为研究对象。留取两组晨起静脉血样用于血清TCF7L2和β-catenin表达水平测定。分析血清中TCF7L2和β-catenin与患者临床特征及顺铂化疗敏感性的关系。结果:观察组患者血清TCF7L2和β-catenin表达水平显著高于对照组(均P<0.05)。观察组患者FIGO分期Ⅳa期、肿瘤低分化者血清中TCF7L2、β-catenin表达水平明显高于FIGO分期Ⅱb期、Ⅲ期和肿瘤高分化者,FIGO分期Ⅲ期明显高于FIGO分期Ⅱb期,出现淋巴转移者高于无淋巴转移者(均P<0.05);同时顺铂化疗不敏感者血清TCF7L2、β-catenin表达水平明显高于敏感者(均P<0.05)。Logistic回归分析显示,血清中TCF7L2、β-catenin高表达是顺铂化疗不敏感的危险因素(均P<0.05)。结论:宫颈癌患者中TCF7L2异常高表达,且其高表达可能是导致患者顺铂化疗耐药的原因之一。

Objective:To investigate the expression level of transcription factor 7-like 2(TCF7L2)in patients with cervical cancer and its correlation with cisplatin chemotherapy sensitivity.Methods:A total of 68 patients with cervical cancer(observation group)and 68 patients with normal physical examination(control group)were collected as research objects.The expression levels of serum TCF7L2 andβ-catenin were measured by morning venous blood samples from two groups.The relationship of serum TCF7L2 andβ-catenin with clinical features and cisplatin sensitivity was analyzed.Results:The expression levels of serum TCF7L2 andβ-catenin in observation group were significant in control group(all P<0.05).The serum expression levels of TCF7L2 andβ-catenin in patients with FIGO stageⅣa and low tumor differentiation were significantly higher than those of patients with FIGO stageⅡb andⅢand patients with high tumor differentiation,the expression levels of TCF7L2 andβ-catenin in patients with FIGO stageⅢwere significantly higher than those of patients with FIGO stageⅡb,and the expression levels of TCF7L2 andβ-catenin in patients with lymphatic metastasis were higher than those without lymphatic metastasis(all P<0.05).At the same time,the expression levels of TCF7L2 andβ-catenin in patients with insensitive cisplatin chemotherapy were significantly higher than those of sensitive patients(all P<0.05).Logistic regression analysis showed that the high expressions of TCF7L2 andβ-catenin were risk factor for insensitivity to cisplatin chemotherapy(all P<0.05).Conclusion:The abnormal high expression of TCF7L2 in patients with cervical cancer may be one of the reasons leading to cisplatin resistance.