MRI联合血清赖氨酸氧化酶样蛋白4、信号转导和转录激活因子3检测用于原发性肝癌诊断的价值

Value of MRI combined with serum LOXL4 and STAT3 levels detection in diagnosis of primary liver cancer

目的:探讨磁共振成像(MRI)联合血清赖氨酸氧化酶样蛋白4(LOXL4)、信号转导和转录激活因子3(STAT3)检测用于原发性肝癌诊断的价值。方法:选取肝占位性病变患者214例,比较分析原发性肝癌和肝脏良性病变患者血清LOXL4、STAT3水平差异,以及原发性肝癌不同患者间差异,同时分析MRI联合血清LOXL4、STAT3水平诊断原发性肝癌的价值。结果:确诊为原发性肝癌患者92例,肝脏良性病变122例。原发性肝癌患者血清LOXL4、STAT3明显高于肝脏良性病变患者(均P<0.05)。TNM分期Ⅲ-Ⅳ患者血清LOXL4、STAT3明显高于肝脏良性病变患者(均P<0.05)。低分化患者血清LOXL4、STAT3明显高于中高分化患者(均P<0.05)。血清LOXL4、STAT3水平诊断原发性肝癌的ROC曲线下面积分别为0.890和0.896(均P<0.05)。MRI联合血清LOXL4、STAT3水平诊断原发性肝癌的灵敏性和阴性预测值分别为95.65%和96.00%,高于MRI检查(均P<0.05)。结论:原发性肝癌患者血清LOXL4、STAT3水平升高,与TNM分期及分化程度有关;MRI联合血清LOXL4、STAT3检测诊断原发性肝癌有较好的应用价值。

Objective:To explore the value of magnetic resonance imaging(MRI)combined with serum levels of lysine oxidase like protein 4(LOXL4)and signal transduction and transcriptional activation factor 3(STAT3)in the diagnosis of primary liver cancer.Methods:A total of 214 patients with liver space occupying lesions were selected,the differences in serum LOXL4 and STAT3 levels between patients with primary liver cancer and those with benign liver lesions were compared and analyzed,as well as the differences between different patients with primary liver cancer.At the same time,the value of MRI combined with serum LOXL4 and STAT3 levels in diagnosing primary liver cancer were analyzed.Results:There were 92 patients diagnosed with primary liver cancer and 122 cases with benign liver lesions.The serum levels of LOXL4 and STAT3 in patients with primary liver cancer were significantly higher than those in patients with benign liver lesions(all P<0.05).The serum levels of LOXL4 and STAT3 in TNM stageⅢtoⅣpatients were significantly higher than those in patients with benign liver lesions(all P<0.05).The serum levels of LOXL4 and STAT3 in patients with low differentiation were significantly higher than those in patients with medium to high differentiation(all P<0.05).The areas under the ROC curve for diagnosing primary liver cancer with serum LOXL4 and STAT3 levels were 0.890 and 0.896,respectively,and the sensitivity and negative predictive values of MRI combined with serum LOXL4 and STAT3 levels in diagnosing primary liver cancer were 95.65%and 96.00%respectively,which were higher than those of MRI examination(all P<0.05).Conclusion:The elevated levels of serum LOXL4 and STAT3 in patients with primary liver cancer are related to TNM staging and differentiation degree.The combination of MRI and serum levels of LOXL4 and STAT3 has good application value in the diagnosis of primary liver cancer.