槐杞黄颗粒联合硫酸沙丁胺醇布地奈德雾化吸入治疗支气管哮喘合并肺炎患儿的效果及对炎症因子肺功能的影响

Effects of Huaiqihuang Granules combined with salbutamol sulfate and budesonide aerosol inhalation on children with bronchial asthma complicated with pneumonia and the influence on inflammatory factors and pulmonary function

目的 探究槐杞黄颗粒联合硫酸沙丁胺醇、布地奈德雾化吸入治疗支气管哮喘(BA)合并肺炎患儿的效果及对炎症因子、肺功能的影响。方法 研究对象为2023年1月至12月在浙江省宁波市镇海区中医医院就诊的160例BA合并肺炎患儿,按治疗方法分为对照组(80例)和观察组(80例),对照组给予硫酸沙丁胺醇联合布地奈德混悬液雾化吸入治疗,观察组联合槐杞黄颗粒治疗,观察2组临床症状消失时间;并进行肺功能检测及血清炎症因子检测。结果 观察组总有效率高于对照组(P<0.05);观察组临床症状消失时间短于对照组(P<0.05);治疗7 d后,观察组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)以及FEV1/FVC比值均高于对照组(P<0.05);观察组肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-4、IL-6水平均低于对照组(P<0.05);2组治疗期间均未发生不良反应。结论 与硫酸沙丁胺醇、布地奈德混悬液雾化吸入治疗相比,联合槐杞黄颗粒治疗BA合并肺炎患儿疗效更确切,更利于临床症状缓解,改善肺功能障碍、降低炎症反应效果更显著。

Objective To investigate the effects of Huaiqihuang Granules combined with salbutamol sul-fate and budesonide aerosol inhalation on children with bronchial asthma(BA)complicated with pneumonia and the influence on inflammatory factors and pulmonary function.Methods A total of 160 children with BA com-plicated with pneumonia who were treated in Ningbo Zhenhai District Hospital of Traditional Chinese Medicine from January to December 2023 were divided into a control group(n=80)and an observation group(n=80)by treatment.Children in the control group were treated with salbutamol sulfate and budesonide aerosol inhalation,while the children in the observation group were treated additionally with Huaiqihuang Granules.Observing and comparing the disappearance time of clinical symptoms,lung function,and serum inflammatory factors between the two groups.Results The total effective rate in the observation group was significantly higher than that in the control group(P<0.05);the disappearance time of clinical symptoms in the observation group was shorter than that in the control group(P<0.05).After 7 days of treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC ratio in the observation group were all higher than those in the control group(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-4,and IL-6 in the observation group were all lower than those in the control group(P<0.05).No adverse reactions occurred in either group during the treat-ment period.Conclusion Compared with salbutamol sulfate and budesonide aerosol inhalation,the combined treatment with Huaiqihuang Granules is more effective in the treatment of children with BA and pneumonia.It can relieve clinical symptoms,improve pulmonary function,and reduce inflammatory response more significantly.