牙周病和龋病相关性分析-基于NHANES数据库对真实世界的研究

Association analysis between periodontitis and dental caries:Real world cross-sectional study based on NHANES database

目的:基于真实世界数据库探讨牙周病和龋病的相关性,为疾病诊疗和健康管理提供理论依据。方法:下载2011年至2014年美国国家健康和营养调查(NHANES)数据库中牙周病和龋病状况检查数据,按照疾病严重程度有序分组,采用广义有序Logistic回归模型进行相关性分析。结果:研究共纳入参与者6299例,轻度、中度和重度牙周炎发病率分别为42.34%、28.15%和11.53%;轻度、中度和重度龋病发病率分别为19.60%、28.34%和35.61%。对于牙周炎,年龄增长、低收入水平、男性、过度饮酒、糖尿病、高血压、中重度抽烟都是加重病情的危险因素。重度龋病和牙周病加重风险升高显著相关,轻度和中度龋病无显著影响。对于龋病,高血压、女性、低收入水平、年龄增长、重度抽烟都是加重病情的危险因素。所有类型牙周病都与龋病加重风险升高显著相关。结论:牙周病和龋病关联十分紧密,它们发生发展具有彼此促进作用,牙周病对龋病病情影响更大。

AIM:To explore the correlation between periodontitis and dental caries based on real-world databases to provide a theoretical basis for the management of both diseases.METHODS:The carious and periodontal examination data from 2011 to 2014 were downloaded from the National Health and Nutrition Examination Survey(NHANES)database.The participants were grouped orderly according to disease severity.The generalized ordered Logistic regression models were used for the correlation analysis.RESULTS:A total of 6299 participants were included in this study,with prevalence of 42.34%,28.15%,and 11.53%for mild,moderate,and severe periodontitis,respectively;and prevalence of 19.60%,28.34%,and 35.61%for mild,moderate,and severe dental caries,respectively.For periodontitis,increasing age,low income,males,excessive alcohol consumption,diabetes,hypertension,and moderate to heavy smoking were risk factors for periodontitis exacerbation.Severe caries was significantly associated with higher risk of periodontal deterioration,while mild and moderate caries had no significant effect.For caries,hypertension,females,low income,increasing age,and heavy smoking were risk factors for exacerbation.All types of periodontitis were significantly correlated with higher risk of carious exacerbation.CONCLUSION:Periodontitis and dental caries are strongly associated,and they contribute to each other’s development,with periodontitis having a greater impact on the carious development and occurrence.