195例农村惊厥性癫痫患者丙戊酸钠治疗情况

Efficacy of valproic acid monotherapy in rural patients with convulsive epilepsy:An analysis of 195 cases

目的 评价2015—2020年江苏省部分农村地区丙戊酸钠单药治疗的惊厥性癫痫患者的效果。方法 对进入该组的惊厥癫痫患者开展丙戊酸钠单药治疗及跟踪管理。评价分析患者的临床特征、服药剂量、药物疗效以及不良反应等。结果 本研究入组惊厥性癫痫患者共195例,其中男性117例。48.72%的癫痫患者丙戊酸钠治疗最大服用剂量≤600 mg/d。193例患者随访满1年,治疗有效率为74.09%。79例患者随访满5年,累积治疗有效率增长至87.34%。随着疗程增加,不良反应发生率逐步下降,主观感觉病情改善的患者比例升高。结论 丙戊酸钠单药治疗效果显著,患者出现不良反应的程度较轻,可推荐用于农村惊厥性癫痫的治疗。

Objective To investigate the efficacy of valproic acid monotherapy in patients with convulsive epilepsy in several rural areas of Jiangsu Province,China,in 2005—2020.Methods The patients with convulsive epilepsy were given valproic acid monotherapy and follow-up management,and they were analyzed in terms of clinical features,medica-tion dose,drug efficacy,and adverse reactions.Results A total of 195 patients with convulsive epilepsy were enrolled in this study,among whom there were 117 male patients.Among these patients,48.72%were treated with valproate acid at a maximum dose of≤600 mg/d.In this study,193 patients were followed up for 1 year,with a response rate of 74.09%,and 79 patients were followed up for 5 years,with a cumulative response rate increasing to 87.34%.The incidence rate of adverse reactions gradually decreased with the increase in the course of treatment,and there was an increase in the propor-tion of patients with a subjective feeling of improvement in their conditions.Conclusion Valproic acid monotherapy has a marked clinical effect with slight adverse reactions,and thus it can be widely used in the treatment of patients with con-vulsive epilepsy in rural areas.