雌激素和Candidalysin在外阴阴道念珠菌病中的研究进展

Research Progress on Estrogen and Candidalysin in Vulvovaginal Candidiasis

外阴阴道念珠菌病(VVC)主要由白念珠菌(CA)引起。增加外周血雌激素水平如怀孕、口服避孕药的使用和激素替代疗法等增加VVC易感性。雌激素可通过调控CA菌丝生长、宿主固有免疫细胞和阴道上皮细胞的免疫功能等多种方式影响VVC进展,但具体机制仍不清楚。Candidalysin(CL)是一种对黏膜感染至关重要的真菌肽毒素,在CA感染中起着重要作用。CL由ECE1基因编码,雌激素调控ECE1表达。本文就雌激素和CL与VVC之间相关性进行综述,为进一步明确雌激素和CL在VVC发病机制中的作用提供参考。

Candida albicans(CA)is the predominant cause of vulvovaginal Candidiasis(VVC).Increasing circulatory estrogen levels such as pregnancy,the use of oral contraceptives,and hormone replacement therapy predispose women to VVC.Estrogen affects the progression of VVC by regulating the growth of CA hyphae,the immune response of the innate immune cells and epithelial cells of host vaginal,but the mechanism is unclear till now.Candidalysin(CL)is a fungal peptide toxin critical for mucosal infection and plays an important role in the CA infection.CL was encoded by ECE 1,which was regulated by estrogen.This article reviews the correlation between estrogen,CL,and VVC for further clarifying the role of estrogen and CL in the pathogenesis of VVC.