双相障碍数字表型的临床应用和挑战

Clinical applications and challenges of digital phenotypes for bipolar disorder

双相障碍是一种常见的精神障碍, 具有起病年龄早、易复发、慢性化的特点, 如何提高治愈率、降低复发率, 是临床诊疗的重点。随着数字医疗的快速发展, 数字表型在双相障碍临床诊疗具有积极的应用前景, 其通过实时记录患者在真实生活环境中的生理、心理、活动等数据, 给双相障碍的临床诊治带来了新的机遇和挑战。现有研究已初步证实, 数字表型在双相障碍的诊断、治疗、病情管理和流行病学监测等方面的积极价值。作为一种新型诊疗技术, 数字表型在临床应用中不仅面临着数据的隐私和安全、技术的可靠性和有效性、算法的迭代和模型的优化以及跨学科合作和整合等共性问题, 也需要着力解决双相障碍临床重点关切的诊治问题。基于数字表型的数字医疗, 将全面提升双相障碍诊治的可及性、有效性和公平性。

Bipolar disorder typically onset during adolescence and is featured with recurrent episodes and chronicity.The clinical management of bipolar disorder aims to enhance cure rates and reduce recurrence rates.With the rapid advancement of digital digital healthcare,digital phenotype approach shows promise in the clinical diagnosis and treatment of bipolar disorder,presenting both new opportunities and challenges.This approach captures real-time physical,psychological,and activity data from patients.Previous studies have initially validated the usefulness of digital phenotype in the diagnosis,treatment,management,and epidemiological surveillance of bipolar disorder.However,as a novel diagnostic and treatment tool,the application of digital phenotype faces challenges related to data privacy and security,technical reliability and validity,algorithmic iteration and model optimisation,as well as interdisciplinary cooperation and integration.Simultaneously,it has to address critical issues in the clinical management of bipolar disorder.Digital healthcare based on digital phenotype is poised tocomprehensively promote the accessibility,efficiency,and justification of bipolar disorder diagnosis and treatment.