摘要
目的分析乌鸡白凤丸联合文拉法辛对产后抑郁(PPD)患者载脂蛋白B(ApoB)、微小RNA(miR)-195的影响。方法选取2022年7月至2023年6月在浙江省温州市第七人民医院治疗的150例PPD患者,按随机数字表法将患者分为对照组75例、研究组75例,对照组患者使用文拉法辛药物治疗,研究组患者使用乌鸡白凤丸联合文拉法辛治疗,检测2组患者的ApoB、5-羟色胺(5-HT)、去甲肾上腺素(NE)、性激素、miR-195、miR-124、匹兹堡睡眠质量指数(PSQI)、爱丁堡产后抑郁量表(EPDS)评分,对比2组患者临床疗效及不良反应。结果与治疗前相比,治疗后2组患者ApoB、黄体酮、miR-124、PSQI评分、EPDS评分水平降低,且治疗后研究组低于对照组(P<0.05);与治疗前相比,治疗后2组患者5-HT、NE、雌二醇、miR-195水平升高,且治疗后研究组高于对照组(P<0.05);与对照组相比,研究组治疗总有效率较高(P<0.05)。2组之间的不良反应发生率差异无统计学意义(P>0.05)。结论乌鸡白凤丸联合文拉法辛治疗可以缓解患者的焦虑情绪,提高其睡眠及生活质量,治疗效果明显。
Objective To analyze the effects of Wuji Baifeng Pill combined with venlafaxine on ApoB and miR-195 in patients with postpartum depression(PPD).Methods A total of 150 patients with postpartum depression treated in the Wenzhou Seventh People′s Hospital from July 2022 to June 2023 were selected.All patients were divided into a control group(75 cases)and a study group(75 cases)by random number table method.The control group was treated with venlafaxine,while the study group was treated with Wuji Baifeng Pill combined with venlafaxine.The levels of ApoB,5-hydroxytryptamine(5-HT),norepinephrine(NE),sex hormones,miR-195,miR-124,Pittsburgh Sleep Quality Index(PSQI),and Edinburgh Postnatal Depression Scale(EPDS)scores were measured in both groups.The clinical efficacy and adverse reactions of the two groups were compared.Results Compared with before treatment,the levels of ApoB,P,miR-124,PSQI scores,and EPDS scores in both groups decreased after treatment,and the study group was lower than the control group after treatment(P<0.05).Compared with before treatment,the levels of 5-HT,NE,E2,and miR-195 in both groups increased after treatment,and in the study group was higher than the control group after treatment(P<0.05).Compared with the control group,the patients in the study group showed higher overall treatment effectiveness after treatment(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Wuji Baifeng Pill combined with venlafaxine can effectively alleviate patients′anxiety,en-hance their sleep quality,and improve their overall quality of life,demonstrating a notable therapeutic outcome.
作者
张秀澄
陈亮
陈光东
平晶
王丽娜
王峰
Zhang Xiucheng;Chen Liang;Chen Guangdong;Ping Jing;Wang Lina;Wang Feng(Department of General Psychiatry,Wenzhou Seventh People′s Hospital,Wenzhou,Zhejiang 325000,China;Department of Intensive Psychiatry,Wenzhou Seventh People′s Hospital,Wenzhou,Zhejiang 325000,China;Department of TCM,Wenzhou Seventh People′s Hospital,Wenzhou,Zhejiang 325000,China)
出处
《中国药物与临床》
CAS
2024年第19期1225-1229,共5页
Chinese Remedies & Clinics
基金
浙江省温州市科技计划项目(Y20170361)。
关键词
乌鸡白凤丸
盐酸文拉法辛
抑郁症
产后
载脂蛋白类
性腺甾类激素
Wu Ji Bai Feng Wan
Venlafaxine hydrochloride
Depression,postpartum
Apolipopro-teins
Gonadal steroid hormones