基于“肝-脾”代谢免疫对话探究慢性心理应激调控肿瘤微环境的科学内涵

Exploring Scientific Connotation of Chronic Psychological Stress Mediated Tumor Microenvironment from"Liver-Spleen"

肿瘤周围的组织、免疫细胞、血管和细胞外基质共同形成的“肿瘤微环境”促进了肿瘤的增殖与侵略,从而增加了癌症的发生、发展与死亡。目前研究表明慢性心理应激可通过调控代谢和免疫功能影响肿瘤微环境,进而诱导肿瘤进程。中医情志致病可致脏腑失调,其中肝脾失调是肿瘤微环境形成的核心病机。基于中医“情志致病”理论,从“肝-脾”代谢免疫层面系统探讨了慢性心理应激介导肿瘤微环境的科学内涵,深入探索情志失调所致肿瘤微环境的肝郁和脾虚本质,从而揭示慢性心理应激介导肿瘤微环境诱导恶性肿瘤的发生发展规律,并为进一步阐述慢性心理应激介导肿瘤微环境促进肿瘤的发病机制以及为情志致癌的诊疗提供新思路。

The“tumor microenvironment”formed by the tissues,immune cells,blood vessels and extracellular matrix around the tumor promotes the proliferation and invasion of the tumor,thereby increasing the occurrence,development and death of cancer.Current studies have shown that chronic psychological stress can affect the tumor microenvironment by regulating metabolism and immune function,thereby inducing tumor progression.Traditional Chinese medicine can cause internal organ disorders,among which liver and spleen disorders are the core pathogenesis of tumor microenvironment formation.Based on the theory of“emotional disease”in traditional Chinese medicine,this paper systematically discussed the scientific connotation of chronic psychological stress-mediated tumor microenvironment from the“liver-spleen”metabolic immunity level,and deeply explored the nature of liver depression and spleen deficiency in the tumor microenvironment caused by emotional disorders,thereby revealing the law of occurrence and development of malignant tumors induced by chronic psychological stress mediated tumor microenvironment,and providing new ideas for further elaboration of the pathogenesis of chronic psychological stress mediated tumor microenvironment to promote tumor pathogenesis and for the diagnosis and treatment of emotional carcinogenesis.