植物内吞体分选转运复合物(ESCRT)调控逆境胁迫响应的研究进展

Research advances on the plant ESCRT machinery regulation of stress responses

逆境胁迫是导致全球农作物产量下降的主要原因之一。当植物受到胁迫时,细胞内蛋白质运输途径需要迅速调整,以确保与应激反应相关的货物分子能通过内膜系统被正确递送到效应位点。真核生物的内膜系统由多种细胞器构成,这些细胞器在有序调控下被准确而高效地生成,参与细胞内物质运输。内吞体分选转运复合物(ESCRT)参与调控液泡前体/多囊泡体的生物学发生过程,并促使了泛素化蛋白从内吞体到液泡的运输过程。本研究重点概述了ESCRT在植物逆境胁迫响应方面的最新研究成果,包括ESCRT的基本组成和功能,以及ESCRT在植物非生物胁迫(干旱、盐胁迫)和先天免疫中的调控作用。探究ESCRT如何特异性识别并调控逆境胁迫响应蛋白,将有助于构建更为精准的ESCRT介导逆境响应的分子调控网络。图2表1参70.

Stress is one of the major reasons causing global crop yield decline.Under stress conditions,the intracellular protein trafficking needs to be adjusted rapidly to ensure the correct delivery of the associated cargo molecules via endomembrane system.The endomembrane system in eukaryotic cells contains diverse membrane-bound organelles,which are accurately and efficiently generated in a well-organized way.These organelles play essential roles in protein transport.The endosomal sorting complex required for transport(ESCRT)complex mediates the biogenesis of prevacuolar compartment/multivesicular body(PVC/MVB),facilitating the vacuolar trafficking of the ubiquitinated proteins.This review highlights the recent research on ESCRT machinery in plant stress responses,including the basic composition and function of ESCRT,and the regulatory role of ESCRT in plant abiotic stress(i.e.drought and salt stress)and innate immunity.To explore how ESCRT specifically recognizes and regulates stress response proteins,it will be helpful to construct a more precise ESCRT-mediated molecular regulatory network of stress responses.[Ch,2 fig.1 tab.70 ref.]