应用磁共振成像评价神经血管耦合功能的研究进展

Research Progress in Evaluating Neurovascular Coupling Function by Magnetic Resonance Imaging

神经血管耦合揭示了大脑神经元活动与脑血流之间的紧密联系,为中枢神经影像的生成和发展提供了全新的研究角度。然而,神经血管耦合能运用在临床上的技术,主要通过经颅多普勒超声、单光子发射体层摄影以及氙清除技术等;这些技术由于不能深入探究疾病背后的病理过程,因此在很大程度上制约了它们的广泛应用和推广。与前述技术相比,磁共振成像展现出更高的软组织分辨率和零辐射的优势,因此近些年经在磁共振成像在神经血管耦合检测中得到了广泛应用。针对神经血管耦合功能现阶段已经进行了众多的实际操作研究,并且取得了新的进展。本文对这些磁共振成像技术进行描述,为广大的研究学者提供新的认识。

Neurovascular coupling reflects the close relationship between neuronal activity in the brain and cerebral blood flow,which provides a new perspective for the occurrence and development of central nervous imaging.However,neurovascular coupling can be applied clinically mainly through transcranial Doppler ultrasound,single photon emission tomography and xenon scavenging technology.The inability of these technologies to better understand the pathologic mechanisms of diseases limits their application to a large extent.Compared with the above techniques,magnetic resonance imaging has higher soft tissue resolution,no radiation and other advantages,so in recent years,magnetic resonance imaging has been widely used in the detection of neurovascular coupling.A great deal of practical work has been carried out on the study of neurovascular coupling function,and new progress has been made.In this paper,these magnetic resonance imaging techniques are described to provide a new understanding for researchers.