血管性介入治疗在宫颈癌大出血患者中的临床疗效

Clinical efficacy analysis of vascular intervention in the treatment of cervical cancer massive hemorrhage

目的:探讨血管性介入治疗宫颈癌大出血的临床疗效及价值。方法:回顾性分析2019年12月至2022年3月在郑州大学第一附属医院就诊的54例宫颈癌大出血患者的临床资料,所有患者均行数字减影血管造影下肿瘤血管灌注化疗栓塞术,并搜集相关临床数据进行分析。结果:经过介入治疗,所有患者出血均得到有效控制。与出血前比较,术后即刻的血红蛋白、红细胞压积及血压下降,心率明显升高,差异有统计学意义(P<0.05)。与术后即刻比较,术后72 h的血红蛋白及红细胞压积变化不明显,差异无统计学意义(P>0.05);血压升高及心率下降较明显,差异有统计学意义(P<0.05)。介入平均手术时间为(52.5±10.2)min。所有患者术后均未观察到严重不良反应事件,不良反应主要为腹痛、发热、恶心呕吐等胃肠道反应,经对症治疗后,不良反应均在1周内完全缓解。结论:血管性介入治疗宫颈癌大出血具有疗效确切、创伤小的特点,具有重要作用及临床价值。

Objective To investigate the clinical efficacy and value of vascular intervention in the treatment of massive hemorrhage in cervical cancer.Methods A total of 54 patients with massive hemorrhage of cervical cancer treated in our hospital from December 2019 to March 2022 were retrospectively analyzed.They underwent tumor vascular infusion chemoembolization under DSA,and the relevant clinical data were collected and analyzed.Results After interventional treatment,all patients'bleeding was effectively controlled.The hemoglobin,hematocrit and blood pressure decreased immediately after surgery and before hemorrhage,and the heart rate increased significantly,the difference was statistically significant(P<0.05).The changes of hemoglobin and hematopoietic volume immediately after surgery and 72 hours after surgery were not significant(P>0.05),but the increase of blood pressure and the decrease of heart rate were significant(P<0.05).The mean operation time was(52.5±10.2)min.No serious adverse events were observed in all patients,and the main adverse reactions were abdominal pain,fever,gastrointestinal reactions such as nausea and vomiting.After symptomatic treatment,the adverse reactions were completely relieved within 1 week.Conclusion Vascular intervention in the treatment of massive hemorrhage of cervical cancer has the characteristics of exact curative effect and small trauma,which has important role and clinical value.