血脂异常与神经系统脱髓鞘疾病的相关性研究进展

Progress in the study of the correlation between dyslipidemia and demyelinating diseases of the nervous system

神经系统脱髓鞘疾病是神经系统的一大类疾病,以髓鞘脱失伴炎性细胞浸润为主要病理特点,可发生于中枢或周围神经系统。前者主要包括多发性硬化症(MS)、视神经脊髓炎谱系疾病(NMOSD),后者主要以吉兰-巴雷综合征(GBS)为代表。研究表明血脂水平异常可能与神经系统脱髓鞘疾病的发生和发展有关,但国内对相关进展的分析总结较少。因此,本文综述血脂异常与神经系统脱髓鞘疾病的关联性研究进展,深入探讨血脂异常与神经系统脱髓鞘疾病之间的相互关系,为神经系统脱髓鞘疾病的预防和治疗提供参考。

Demyelinating disorders of the nervous system constitute a broad spectrum of neurological conditions characterized by the depletion of myelin sheaths accompanied by inflammatory cell infiltration,manifesting in either the central or peripheral nervous system.The former primarily encompasses conditions such as multiple sclerosis(MS)and neuromyelitis optica spectrum disorders(NMOSD),while the latter is exemplified predominantly by Guillain-Barre syndrome(GBS).Recent investigations have revealed that dyslipidemia may be related to the occurrence and development of neurological demyelination,but there are fewer analyses and summaries of related advances in China.Consequently,this review aims to comprehensively outline advancements in research concerning the correlation between dyslipidemia and neurological demyelinating disordersand discusses in depth the interrelationship between dyslipidemia and neurological demyelinating diseases,so as to provide reference for the prevention and treatment of neurological demyelinating diseases.