良性前列腺增生患者糖脂等指标与前列腺体积的相关性研究

Study on the correlation between glycolipids and prostate volume in patients with benign prostatic hyperplasia

研究良性前列腺增生患者空腹血糖、脂质代谢指标、前列腺特异性抗原与前列腺体积的临床相关性,以及探讨作为诊断指标的组合效应。回顾性分析2021年6月至2023年3月北京中医药大学第三附属医院就诊的108例良性前列腺增生患者作为增生组,另选取同期98例健康体检人员作为对照组;比较两组患者空腹血糖(fasting plasma glucose,FPG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL)、小而密低密度脂蛋白胆固醇(small and dense low density lipoprotein cholesterol,sdLDL)、同型半胱氨酸(homocysteine,HCY)、脂蛋白a(lipoprotein a,LPa)、前列腺特异抗原(prostate specific antigen,PSA)、游离前列腺特异抗原(free prostate specific antigen,fPSA)水平的差异;采用Pearson分析法分析以上指标与良性前列腺增生患者前列腺体积大小的相关性;采用多元线性回归分析前列腺体积增大的影响因素;绘制受试者工作特征(ROC)曲线,分析HDL、FPG、PSA、fPSA单独及联合检测的应用价值。结果显示,对照组与增生组HDL(P=0.004)、FPG(P=0.026)、PSA(P=0.000)、fPSA(P=0.000)水平具有明显差异(P<0.05);前列腺体积大小与HDL(r=-0.183,P<0.05)呈负相关,与FPG(r=0.202,P<0.05)、PSA(r=0.412,P<0.05)、fPSA(r=0.425,P<0.05)呈正相关;多元线性回归分析结果显示HDL(P=0.000)、FPG(P=0.048)、PSA(P=0.044)、fPSA(P=0.012)是良性前列腺增生体积增大的危险因素;ROC曲线分析显示HDL、FPG、PSA、fPSA联合检测AUC为0.823,优于单独检测。综上,HDL、FPG、PSA、fPSA与前列腺增生有密切相关性,联合检测对良性前列腺增生可能具有较好的预测价值。

To study the clinical correlation between fasting plasma glucose,lipid metabolism,prostate-specific antigen and prostate volume in patients with benign prostatic hyperplasia,and to explore the combined effect as diagnostic indicators.A total of 108 patients with benign prostatic hyperplasia treated in Beijing University of Chinese Medicine Third Affiliated Hospital from June 2021 to March 2023 were retrospectively analyzed as the hyperplasia group,and 98 healthy physical examination personnel were selected as the control group during the same period.Compare the differences in levels of fasting plasma glucose(FPG),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),small and dense low-density lipoprotein cholesterol(sdLDL-C),homocysteine,lipoprotein a(LPa),prostate specific antigen(PSA),and free prostate specific antigen(fPSA)between two groups of patients.Using Pearson analysis method to analyze the correlation between the above indicators and the size of prostate volume in patients with benign prostatic hyperplasia;using multiple linear regression to analyze the influencing factors of prostate volume enlargement;draw receiver operating characteristic(ROC)curves and analyze the application value of individual and combined detection of HDL,FPG,PSA,and fPSA.The results showed that there were significant differences in HDL,FPG,PSA,and fPSA levels between the control group and the proliferative group(P<0.05).The size of prostate volume is negatively correlated with HDL(r=-0.183,P<0.05)and positively correlated with FPG(r=0.202,P<0.05),PSA(r=0.412,P<0.05),and fPSA(r=0.425,P<0.05).The results of multiple linear regression analysis showed that HDL(P=0.000),FPG(P=0.048),PSA(P=0.044),and fPSA(P=0.012)were risk factors for increased volume of benign prostatic hyperplasia;ROC curve analysis shows that the AUC of HDL,FPG,PSA,and fPSA combined detection is 0.823,which is better than individual detection.In conclusion,HDL,FPG,PSA,fPSA has close correlation with hyperplasia of prostate,the joint detection may has better prediction for benign prostatic hyperplasia.