N-乙酰半胱氨酸联合乙胺吡嗪利福异烟辅助渐进性肌肉放松训练治疗继发性肺结核合并COPD疗效及T淋巴细胞影响的临床研究

A clinical study on the therapeutic effect and T lymphocyte impact of N-acetylcysteine combined with ethylpyrazine rifampicide smoke assisted progressive muscle relaxation training in the treatment of secondary pulmonary tuberculosis complicated with COPD

目的探讨N-乙酰半胱氨酸联合乙胺吡嗪利福异烟辅助渐进性肌肉放松训练治疗继发性肺结核合并慢性阻塞性肺疾病(COPD)疗效及对T淋巴细胞的影响.方法选择2023年1月-2023年6月于粤北第二人民医院接受治疗的60例肺结核合并COPD患者作为观察对象,采取随机数字表法分为观察组和对照组,在均给予常规对症治疗基础上,对照组采用N-乙酰半胱氨酸片辅助渐进性肌肉放松训练治疗,观察组采用N-乙酰半胱氨酸片联合乙胺吡嗪利福异烟辅助渐进性肌肉放松训练治疗.对比观察两组患者的临床疗效、肺功能测定指标、T淋巴细胞水平及生活质量.结果观察组治疗总有效率高于对照组(P<0.05);观察治疗后的FEV1、FVC及FEV1/FVC等肺功能指标均高于对照组(P<0.05);观察组治疗后的CD8+低于对照组,CD3+、CD4+和CD4+/CD8+高于对照组(P<0.05);观察组治疗后的圣乔治呼吸问卷评分低于对照组(P<0.05).结论N-乙酰半胱氨酸联合乙胺吡嗪利福异烟辅助渐进性肌肉放松训练治疗继发性肺结核合并COPD,可以显著改善患者的肺功能和T淋巴细胞水平,提高其整体疗效和生活质量,值得推广.

Objective To explore the clinical efficacy and T lymphocyte impact of N-acetylcysteine combined with ethylpyrazine rifampicide smoke assisted progressive muscle relaxation training in the treatment of secondary pulmonary tuberculosis complicated with chronic obstructive pulmonary disease(COPD).Methods Sixty patients with pulmonary tuberculosis complicated with COPD who received treatment in our department from January 2023 to June 2023 were selected as the observation subjects.They were randomly divided into an observation group and a control group,both receiving routine symptomatic treatment.The control group received N-acetylcysteine tablets as an adjunct to progressive muscle relaxation training,while the observation group received N-acetylcysteine tablets combined with amiodarone and rifampicin as an adjunct to progressive muscle relaxation training.Compare and observe the therapeutic effects,lung function measurements,T lymphocytes,and quality of life of two groups of patients.Results The total effective rate of the observation group was higher than that of the control group(P<0.05);the lung function indicators such as FEV1,FVC,and FEV1/FVC after treatment were observed to be higher than those in the control group(P<0.05);after treatment,the CD8+in the observation group was lower than that in the control group,while CD3+,CD4+,and CD4+/CD8+were higher than those in the control group(P<0.05);the Saint George's Respiratory Questionnaire score in the observation group after treatment was lower than that in the control group(P<0.05).Conclusion The combination of N-acetylcysteine and ethampyrazine rifampicin as an adjunct to progressive muscle relaxation training can significantly improve lung function and T lymphocyte levels in patients with secondary pulmonary tuberculosis complicated with COPD,enhance overall efficacy and quality of life,and is worthy of promotion.