盐酸西替利嗪滴剂治疗小儿过敏性皮肤病的疗效及作用机制研究

Study on the efficacy and mechanism of Cetirizine hydrochloride drops in the treatment of allergic skin diseases in children

目的观察盐酸西替利嗪滴剂对小儿过敏性皮肤病用药疗效并分析其药物作用机制.方法将2022年1月-2023年12月北京市平谷区妇幼保健院接收的小儿过敏性皮肤病患儿60例经随机数字表法平均分配于两组当中,每组30例,对照组经扑尔敏口服用药,观察组基于扑尔敏用药后配合使用盐酸西替利嗪滴剂,对比两组用药后的有效性、疼痛评分、炎性介质和T细胞亚群水平、不良反应发生情况.结果观察组用药后总有效率96.67%和对照组的73.33%相比更高(P<0.05).两组用药前疼痛感指标评分对比无较大差异(P>0.05);观察组用药后视觉模拟评分法(VAS)评分和对照组相比更低(P<0.05).两组用药前炎性介质水平对比无较大差异(P>0.05);观察组用药后白细胞介素-4(IL-4)、白细胞介素-10(IL-10)及干扰素-γ(IFN-γ)等水平和对照组相比更优(P<0.05).两组用药前T细胞亚群水平对比无较大差异(P>0.05).观察组用药后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平和对照组相比更高,且CD8^(+)水平和对照组相比更低(P<0.05).观察组用药后总不良反应发生率20.00%和对照组的6.67%相比更高,但无统计学差异(P>0.05).结论盐酸西替利嗪滴剂用药后疗效较高,能减轻疼痛和炎性介质刺激,增强免疫能力,且副作用较少.

Objective To observe the therapeutic effect of cetirizine hydrochloride drops on allergic skin diseases in children and to analyze its effects.Methods Sixty children with allergic skin diseases received from Beijing Pinggu District Maternal and Child Health Hospital from January 2022 to December 2023 were evenly divided into two groups by random number table method,30 cases in each group.The control group was given oral prochloramine,and the observation group was given prochloramine combined with cetirizine hydrochloride drops.Efficacy,pain score,levels of inflammatory mediators and T cell subsets,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate was 96.67%in the observation group and 73.33%in the control group(P<0.05).There was no significant difference in the scores of pain perception index between the two groups before medication(P>0.05).The visual analogue scale(VAS)score of observation group was lower than that of control group(P<0.05).There was no significant difference in the levels of inflammatory mediators between the two groups before treatment(P>0.05).The levels of interleukin-4(IL-4),interleukin-10(IL-10)and interferon-γ(IFN-γ)in the observation group were better than those in the control group(P<0.05).There was no significant difference in T cell subsets between the two groups before treatment(P>0.05).The level of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group was higher than that in the control group,and the level of CD8^(+)was lower than that in the control group(P<0.05).The total adverse reactions of 20.00%in the observation group and 6.67%in the control group were slightly higher,but there was no significant difference(P>0.05).Conclusion Cetirizine hydrochloride drops have higher curative effect,can reduce pain and inflammatory media stimulation,enhance immune ability,and have fewer side effects.