阿卡波糖联合二甲双胍治疗2型糖尿病的效果

Effect of acarbose combined with metformin in the treatment of type 2 diabetes mellitus

目的探讨阿卡波糖联合二甲双胍治疗2型糖尿病的临床疗效,寻找更好控制患者血糖的治疗方法。方法选取2019年2月—2021年11月湖北省武汉市武昌区水果湖街社区卫生服务中心收治的2型糖尿病患者200例纳入研究,按照双盲法分为对照组和观察组各100例。对照组给予二甲双胍治疗,观察组给予阿卡波糖联合二甲双胍治疗。比较两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平及不良反应发生率。结果干预前,两组患者血糖指标差异无统计学意义(P>0.05);干预后,观察组空腹血糖为(5.21±1.09)mmol/L、餐后2 h血糖为(7.07±1.55)mmol/L、糖化血红蛋白为(6.31±0.22)%,低于对照组的(6.54±1.67)mmol/L、(8.89±1.87)mmol/L、(7.09±0.51)%,差异均有统计学意义(P<0.05)。观察组不良反应发生率为6.00%,对照组不良反应发生率为4.00%,两组比较差异无统计学意义(P>0.05)。结论阿卡波糖联合二甲双胍治疗2型糖尿病,能明显改善血糖水平,降低不良反应发生率,值得临床推广应用。

Objective To explore the clinical efficacy of acarbose combined with metformin in the treatment of type 2 diabetes mellitus,and to find a better treatment method to control blood sugar of patients.Methods A total of 200 patients with type 2 diabetes mellitus admitted to Hubei Province Wuhan City Wuchang District Shuiguohu Street Community Health Service Center from February 2019 to November 2021 were selected to be included in the study.They were divided into control group and observation group by double-blind method,with 100 cases in each group.The control group was treated with metformin,and the observation group was treated with acarbose combined with metformin.The fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin and the incidence of adverse reactions of the two groups were compared.Results Before intervention,there were no significant differences in blood glucose indicators between two groups(P>0.05).After intervention,in the observation group,the fasting blood glucose was(5.21±1.09)mmol/L,2 h postprandial blood glucose was(7.07±1.55)mmol/L,and glycosylated hemoglobin was(6.31±0.22)%,which were lower than(6.54±1.67)mmol/L,(8.89±1.87)mmol/L and(7.09±0.51)%respectively in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 6.00%,and the incidence of adverse reactions in the control group was 4.00%,there was no significant difference between the two groups(P>0.05).Conclusion For the treatment of type 2 diabetes mellitus,acarbose combined with metformin could significantly improve blood glucose level and reduce the incidence of adverse reactions,which was worthy of clinical promotion and application.