HMGB1调控成骨细胞相关信号通路作用机制研究进展

Progress in the mechanism of HMGB 1 regulation of osteoblast-related signaling

成骨细胞所介导的骨形成功能障碍是临床上常见老年骨代谢相关疾患的病理基础。研究表明晚期糖基化终产物受体(RAGE)、丝裂原活化蛋白激酶(MAPK)、TOLL样受体4/核转录因子-κB(TLR4/NF-κB)、Wnt/β-连环蛋白(Wnt/β-catenin)等信号通路均具有调控成骨细胞、维持骨稳态的能力。而HMGB1作为细胞因子可参与炎症反应,且在调控成骨细胞增殖分化及维持骨稳态等过程中发挥重要作用。因此,本文通过总结上述信号通路与HMGB1干预在成骨细胞的研究现状,旨在为成骨细胞相关研究提供新思路,为促进骨形成维持骨稳态提供理论参考与依据。

The dysfunction of bone formation mediated by osteoblasts is the pathological basis of common bone metabolism-related diseases in the elderly.Studies have shown that signaling pathways such as late end product receptor(RAGE),mitogen-activated protein kinase(MAPK),TOLL-like receptor 4/nuclear transcription factor-κB(TLR 4/NF-κB),and Wnt/β-catenin(Wnt/β-catenin)have the ability to regulate osteoblasts and maintain bone homeostasis.HMGB 1,as a cytokine,participates in inflammatory response and plays an important role in regulating osteoblast proliferation and differentiation and in maintaining bone homeostasis.Therefore,by summarizing the current research status of the above signaling pathway and HMGB 1 intervention in osteoblasts,this paper aims to provide new ideas for osteoblast-related research and to provide theoretical reference and basis for promoting bone formation and maintaining bone homeostasis.