中药调控单胺类神经递质治疗抑郁症的研究进展

Research progress in treatment of depression with traditional Chinese medicine by regulating monoamine neurotransmitters

抑郁症作为一种精神障碍性疾病,严重危害患者身心健康。目前临床治疗抑郁症多以化学药物为主,这类药物主要通过不同作用途径增加突触间隙单胺类神经递质的浓度,改善患者抑郁症状。抑郁症治疗周期较长,尽管化学药物可以在短期内发挥疗效,长期服用时不良反应明显。传统中医药在治疗精神类疾病方面历史悠久、经验丰富,对于抑郁症的防治具有重要意义。单胺类神经递质的调节仍是临床治疗抑郁症最主要的方式,立足于中医基础理论,主要对临床常用单味中药(茯苓、当归、柴胡、白芍、酸枣仁、白术、远志、合欢皮)及复方(逍遥散、开心散、柴胡疏肝散、越鞠丸、半夏厚朴汤)通过调控单胺类神经递质治疗抑郁症的作用机制进行综述,以期发挥传统中医药治疗优势,为抑郁症的中西医结合治疗提供参考。

Depression,as a mental disorder,seriously endangers the physical and mental health of patients.At present,chemical drugs are mainly used in clinical treatment of depression.These drugs mainly increase the concentration of monoamine neurotransmitters in synaptic gaps through different pathways of action,improving the symptoms of depression in patients.Depression lasts for a long period of time,although chemical drugs can have short-term therapeutic effects,adverse reactions are significant when taken for a long time.Traditional Chinese medicine has a long history and rich experience in treating mental illnesses,and is of great significance for the prevention and treatment of depression.The regulation of monoamine neurotransmitters is still the most important way to treat depression in clinical practice.This article reviews the mechanism of action of commonly used traditional Chinese medicine(Poria,Angelica Sinensis Radix,Bupleuri Radix,Paeoniae Radix Alba,Ziziphi Spinosae Semen,Atractylodis Macrocephalae Rhizoma,Polygalae Radix,Albiziae Cortex)and its compound(Xiaoyao Powder,Kaixin Powder,Chaihu Shugan Powder,Yueju Pill,Banxia Houpo Decoction)in treating depression by regulating monoamine neurotransmitters based on the basic theory of traditional Chinese medicine,in order to leverage the advantages of traditional Chinese medicine treatment and provide reference for the integrated diagnosis and treatment of depression.