间充质干细胞治疗自身免疫性疾病的研究进展

Research progress of mesenchymal stem cells in the treatment of autoimmune diseases

自身免疫性疾病(autoimmune diseases,AIDs)是一类发病机制复杂的慢性疾病,机体免疫稳态失衡与其发生发展密切相关。间充质干细胞(mesenchymal stem cells,MSCs)是一类多功能成体干细胞,具有自我更新和分化成各种细胞类型的能力,在免疫调节和组织损伤修复中发挥重要作用,近年来MSCs在治疗AIDs领域得到了广泛关注。本文就近年来MSCs对AIDs治疗中的研究进展进行综述。

Autoimmune diseases(AIDs)are a series of chronic diseases with complex pathogenesis.The imbalance of immune homeostasis is closely related to its occurrence and development.Mesenchymal stem cells(MSCs)are a kind of multifunctional stem cells,which have the ability to self-renew and differentiate into various cell types,play an important role in immune modulation and tissue damage repair.In recent years,MSCs have received extensive attention in the treatment of AIDs.This article reviews the recent advances of MSCs in the treatment of AIDs.