智能控压负压吸引联合输尿管软镜碎石取石术在上尿路结石中的应用

Application of intelligent controlled negative pressure suction combined with flexible ureteroscopic lithotripsy in the treatment of upper urinary tract calculi

目的:探讨智能控压负压吸引联合输尿管软镜碎石取石术在上尿路结石中的应用效果。方法:选择2022年4月—2023年2月曲靖市第二人民医院收治的90例上尿路结石患者为研究对象,采用随机数字法分为观察组和对照组,每组45例。对照组采取输尿管软镜碎石取石术,观察组采取智能控压负压吸引联合输尿管软镜碎石取石术。比较2组的临床疗效、碎石取石结果、手术治疗情况、肾功能[血肌酐(Scr)、尿素氮(BUN)、β2微球蛋白(β2-MG)]、炎性因子水平[C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)]。结果:与对照组比较,观察组临床总有效率显著上升(88.89%vs 100.00%,χ^(2)=11.764,P<0.05)。与对照组比较,观察组术毕时、术后7 d、术后1个月存在残石的患者例数占比显著下降(χ^(2)=7.328、6.870、11.764,均P<0.05)。与对照组比较,观察组平均手术时间、平均住院时间及术后Scr、BUN、β2-MG、CRP、IL-6、PCT值均显著下降(P<0.05)。结论:在上尿路结石中采用智能控压负压吸引联合输尿管软镜碎石取石术治疗方案,能提升手术治疗效果,降低残石率,减轻肾功能损伤及炎症反应,缩短手术时间、住院时间,有助于患者术后恢复。

Objective To investigate the application of intelligent controlled negative pressure suction combined with flexible ureteroscopic lithotripsy in the treatment of upper urinary tract calculi.Methods Ninety patients with upper urinary tract calculi treated in Qujing Second People's Hospital of Yunnan from April 2022 to February 2023 were selected as the study objects.They were divided into 45 cases in each group by random number method.The control group was treated with flexible ureteroscopic lithotripsy,while the observation group was treated with intelligent controlled negative pressure suction combined with flexible ureteroscopic lithotripsy.The clinical efficacy,the results of lithotripsy,surgical treatment,renal function(serum creatinine[Scr],urea nitrogen[BUN],β2-microglobulin[β2-MG])and inflammatory factor levels(C-reactive protein[CRP],interleukin-6[IL-6],procalcitonin[PCT])of the two groups were compared.Results Compared with the control group,the total effective rate of the observation group significantly increased(88.89%vs 100.00%,χ^(2)=11.764,P<0.05).Compared with the control group,the proportion of patients with residual stone in the observation group significantly decreased at the end of operation,7 days after operation and 1 month after operation(χ^(2)=7.328,6.870,11.764,all P<0.05).Compared with the control group,the mean operation time,mean hospital stay and postoperative values of Scr,BUN,β2-MG,CRP,IL-6 and PCT in observation group significantly decreased(P<0.05).Conclusion The application of intelligent controlled negative pressure suction combined with flexible ureteroscopic lithotripsy in upper urinary tract calculi can improve the surgical treatment effect,reduce the rate of residual stone,reduce renal injury and inflammatory reaction,shorten the operation time and hospital stay,and contribute to postoperative recovery.