百日咳的非抗生素治疗策略

Non-antibiotic treatment strategies for pertussis

近年来百日咳鲍特菌对大环内酯类药物的耐药率显著增加,导致传统抗生素治疗的有效性下降。本文提出,尽早识别百日咳的卡他期并进行暴露后预防性给药,强化痉挛性咳嗽的非抗生素药物治疗,重视百日咳毒素所致高凝状态对肺部及全身的影响,以及警惕百日咳继发感染的排查与治疗,是当前治疗百日咳的关键策略。

The rate of resistance to macrolides in Bordetella pertussis has increased significantly in recent years,leading to a decrease in the effectiveness of conventional antibiotic therapy.This article proposes that early recognition of the catarrhal phase of pertussis and post-exposure prophylactic administration,intensive non-antibiotic pharmacological treatment of spasmodic cough,attention to the pulmonary and systemic effects of hypercoagulability due to pertussis toxin,and vigilance in the detection and treatment of secondary infections of pertussis are key strategies in the current treatment of pertussis.