肺炎克雷伯菌与宿主先天性免疫反应的相互作用

Interactions between Klebsiella pneumoniae and host innate immune response

肺炎克雷伯菌是一种常见的有荚膜、不能活动的兼性厌氧革兰阴性菌,其广泛的表型和丰富的遗传特性使其成为公共卫生的严重威胁。此文首先介绍肺炎克雷伯菌感染的流行病学特征;其次探讨肺炎克雷伯菌如何通过产生大量的荚膜多糖以及利用宿主补体系统的差异来逃避宿主血清补体的攻击;最后讨论肺炎克雷伯菌与巨噬细胞、中性粒细胞和骨髓来源抑制细胞样细胞等先天性免疫细胞的相互作用。深入理解以上机制将有助于开发更准确的诊断工具和免疫治疗策略,以便更有效地应对肺炎克雷伯菌的感染。

Klebsiella pneumoniae is a common,non-motile,facultative anaerobic,encapsulated Gram-negative bacterium,posing a serious threat to public health due to its diverse phenotypes and extensive genetic characteristics.This paper introduces the epidemiological characteristics of Klebsiella pneumoniae infection.Subsequently,it explores how Klebsiella pneumoniae evades host serum complement attack by producing abundant capsular polysaccharide and exploiting the differences in the host complement system.Finally,it discusses the interactions between Klebsiella pneumoniae and innate immune cells,including macrophages,neutrophils,and myeloid-derived suppressor cell-like cells.A comprehensive understanding of these mechanisms will facilitate the development of more precise diagnostic tools and immunotherapeutic strategies to effectively control Klebsiella pneumoniae infections.