摘要
细胞外囊泡(extracellular vesicles,EVs)是起源于细胞膜的多囊泡体,EVs在病毒炎性反应中发挥重要作用,可以充当病毒载体,协助病毒的感染和传播;调节细胞炎症通路的表达以及炎症因子的释放;诱导机体免疫应答,抑制病毒复制和传播,发挥抗病毒作用。上皮细胞是病毒入侵肺组织时的首要感染目标,随后巨噬细胞迅速对病毒的感染做出反应,上皮细胞和巨噬细胞之间的"串话"在细胞炎症反应中起重要作用,而细胞释放的EVs在"串话"中发挥关键作用。本文综述了感染不同病毒后,上皮细胞和巨噬细胞释放的EVs在病毒传播及其引发肺部炎症的作用机制。
Extracellular vesicles(EVs)are multivesicular bodies originating from the cell membrane.EVs play an important role in viral infection and inflammation by acting as viral vectors to assist in viral infection and dissemination.Cellular inflammatory pathways and inflammatory factors can also be regulated by EVs.EVs can induce an immune response,inhibit virus replication,thus exerting antiviral effects.Epithelial cells are the primary targets of viral invasion into lung tissue,and macrophages quickly respond to viral infection.EVs released by the cells play a key role in the"crosstalk"between epithelial cells and macrophages,and the"crosstalk"plays an important role in cellular inflammatory response.In this review,the role of EVs released by epithelial and macrophage cells in viral spread and the resulting pulmonary inflammation after infection with different viruses is summarized.
作者
陈染
黄佳佳
王楚雯
钱国清
Chen Ran;Huang Jiajia;Wang Chuwen;Qian Guoqing(Department of Infectious Diseases,the First Affiliated Hospital of Ningbo University,Medical Data Center,the First AffiliatedHospital of NingboUniversity,Ningbo315211,China)
出处
《国际流行病学传染病学杂志》
CAS
2024年第4期278-282,共5页
International Journal of Epidemiology and Infectious Disease
基金
浙江省基础公益研究计划(LY23H190003)
宁波市青年科技创新领军人才项目(2023QL055)
浙江省卫生高层次人才培养基金(浙卫发[2021]-40)。
关键词
上皮细胞
细胞外囊泡
病毒感染
Epithelial cells
Extracellular vesicles
Viral infections
