摘要
目的:分析实验室检测指标在新生儿败血症(NS)早期诊断上的临床价值。方法:选取2020年9月至2023年10月期间在我院进行治疗的91例NS患者纳入研究,另选取79例健康婴儿纳入研究,将上述婴儿分为对照组(n=79)和败血症组(n=91)两组,比对两组血液指标检测结果,多因素logistic回归分析NS的的独立危险因素,绘制受试者工作特征(ROC)曲线分析实验室检测指标对NS的诊断价值。结果:败血症组的白细胞总数(WBC)、中性粒细胞总数(Neu)、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/淋巴细胞比值(MLR)、降钙素原(PCT)、C反应蛋白(CRP)相关血液检测指标高于对照组,差异有统计学意义(P<0.05),淋巴细胞总数(Lym)、淋巴细胞/白细胞比值(LLR)低于对照组,差异有统计学意义(P<0.05),两组单核细胞总数(Mono)差异无统计学意义(P>0.05);多因素logistic回归分析显示,WBC、Neu、Lym、PCT、CRP含量是新生儿发生NS的独立危险因素(P<0.05);ROC曲线分析发现WBC、Neu、Lym、PCT、CRP联合检测预测NS发生的曲线下面积(AUC)最高,为0.960,高于上述指标单独检测。结论:WBC、Neu、Lym、PCT含量、CRP含量是新生儿发生NS的独立危险因素,联合检测对NS早期诊断效能最高。
Objective:To analyze the clinical value of laboratory test indicators in the early diagnosis of neonatal sepsis(NS).Methods:Ninety-one patients with NS and 79 healthy infants treated in our hospital from September 2020 to October 2023 were enrolled in this research.The infants were divided into the control group(n=79)and sepsis group(n=91).The detection results of blood indexes were compared between the two groups.Multivariate logistic regression was used to identify the independent risk factors of NS.The receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of laboratory indexes on NS.Results:The total number of white blood cells(WBC),neutrophilicgranulocyte(Neu),neutrophil-lymphocyte ratio(NLR),monocyte-lymphocyte ratio(MLR),procalcitonin(PCT),and C-reactive protein(CRP)in sepsis group were higher than those in control group(P<0.05),while the total number of lymphocyte(Lym)and lymphocyte-leukocyte ratio(LLR)were lower than those in control group(P<0.05),but there was no statistical difference in the total number of monocyte(Mono)between the two groups(P>0.05).Multivariate logistic regression analysis showed that WBC,Neu,Lym,PCT,and CRP were independent risk factors for neonatal NS(P<0.05).ROC curve analysis found that the area under the curve(AUC)of the combination of WBC,Neu,Lym,PCT,and CRP in predicting the occurrence of NS was the highest at 0.960,higher than that detected by the above indicators alone.Conclusion:WBC,Neu,Lym,PCT,and CRP are independent risk factors for neonatal NS,and combined detection has the highest efficiency in the early diagnosis of NS.
作者
杨清玉
杨续
李维春
YANG Qingyu;YANG Xu;LI Weichun(Chuzhou Hospital,Anhui Medical University,Anhui Chuzhou 239001,China)
出处
《河北医学》
CAS
2024年第9期1530-1534,共5页
Hebei Medicine
基金
2020年度安徽省自然科学基金项目,(编号:2008085QH352)。