瑞马唑仑复合环泊酚在老年无痛结肠镜检查患者中的应用效果

Application Effect of Remimazolam Combined with Ciprofol in Elderly Patients Undergoing Painless Colonoscopy

目的:分析瑞马唑仑复合环泊酚在老年无痛结肠镜检查患者中的应用效果。方法:选取2024年1-4月长沙市中医医院收治的120例老年无痛结肠镜检查患者。根据随机数表法将其随机分为观察组和对照组,各60例。观察组给予瑞马唑仑复合环泊酚麻醉,对照组给予环泊酚麻醉。比较两组麻醉前(T_(1))、肠镜通过肛门(T_(2))、肠镜到达回盲部(T_(3))、检查结束时(T_(4))生命体征,麻醉指标及不良反应。结果:观察组T_(2)、T_(3)、T_(4)平均动脉压(MAP)高于对照组,T_(2)、T_(3)心率(HR)高于对照组,T_(2)经皮血氧饱和度(SpO_(2))高于对照组,差异有统计学意义(P<0.05);两组T_(2)、T_(3)、T_(4)MAP均低于本组T_(1);两组T_(2)、T_(3)HR低于本组T_(1);两组T_(2) SpO_(2)低于本组T_(1),差异有统计学意义(P<0.05)。观察组麻醉起效时间、苏醒时间和离室时间均明显早于对照组,差异有统计学意义(P<0.05)。观察组低血压、呼吸抑制发生率低于对照组,差异有统计学意义(P<0.05)。结论:瑞马唑仑复合环泊酚应用于老年无痛结肠镜检查患者中安全有效,能够减少不良反应,并能够缩短起效时间、苏醒时间和离室时间。

Objective:To analyze the application effect of Remimazolam combined with Ciprofol in elderly patients undergoing painless colonoscopy.Method:A total of 120 elderly patients with painless colonoscopy admitted to Changsha Hospital of Traditional Chinese Medicine from January to April 2024 were selected.According to the method of random number table,they were randomly divided into observation group and control group,60 cases in each group.The observation group was given Remimazolam combined with Ciprofol anesthesia,and the control group was given Ciprofol anesthesia.The vital signs before anesthesia(T_(1)),colonoscopy through the anus(T_(2)),colonoscopy to the ileocecal part(T_(3)),at the end of the examination(T_(4)),anesthesia indexes and adverse reactions of two groups were compared.Result:The mean arterial pressure(MAP)of T_(2),T_(3) and T_(4) in observation group was higher than that in control group,the heart rate(HR)of T_(2),T_(3) in observation group was higher than that in control group,and the percutaneous blood oxygen saturation(SpO_(2))of T_(2) was higher than that of control group,and the differences were statistically significant(P<0.05).The MAP at T_(2),T_(3),T_(4) of two groups were lower than that at T_(1) in this group;HR at T_(2) and T_(3) in two groups were lower than T_(1) in this group;SpO_(2) at T_(2) in two groups was lower than at T_(1) in this group,and the differences were statistically significant(P<0.05).The onset time of anesthesia,recovery time and leaving the room time in the observation group were significantly earlier than those in the control group,and the differences were statistically significant(P<0.05).The incidences of hypotension and respiratory depression in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion:Remimazolam combined with Ciprofol is safe and effective in elderly patients with painless colonoscopy,can reduce adverse reactions,and can shorten the onset time,recovery time and exit time.