米索前列醇配伍钙剂防治产妇产后出血的效果

Effect of Misoprostol Combined with Calcium on Prevention and Treatment of Pregnant Women with Postpartum Hemorrhage

目的:探索米索前列醇配伍钙剂防治产妇产后出血的效果。方法:选取2021年3月—2024年1月建瓯市立医院收治的123例产妇作为研究样本。根据随机抽签方式将其分为对照组(n=62)和观察组(n=61)。对照组给予缩宫素防治产后出血,观察组在对照组基础上给予米索前列醇配伍钙剂防治产后出血。比较两组产后出血情况,治疗前后凝血指标、血流动力学指标、炎症因子及防治效果,不良反应。结果:观察组产后2 h、12 h、24 h出血量均少于对照组,差异有统计学意义(P<0.05)。给药后12 h,两组纤维蛋白原(fibrinogen,FIB)升高,凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)均降低,观察组FIB高于对照组,PT、TT均低于对照组,差异有统计学意义(P<0.05)。给药后12 h,两组阻力指数(resistance index,RI)、搏动指数(pulsatility index,PI)均降低,观察组RI、PI均低于对照组,差异有统计学意义(P<0.05)。给药后12 h,两组白细胞介素-6(interleukin-6,IL-6)、超敏C反应蛋白(hypersensitive C response protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平均降低,观察组IL-6、hs-CRP、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:运用米索前列醇配伍钙剂防治产妇产后出血效果显著,可以有效降低产妇产后出血风险,降低机体炎症因子水平,促使患者尽早恢复正常生理功能。

Objective:To explore the effect of Misoprostol combined with Calcium on prevention and treatment of pregnant women with postpartum hemorrhage.Method:A total of 123 pregnant women admitted to Jian’ou Municipal Hospital from March 2021 to January 2024 were selected as research samples.They were divided into control group(n=62)and observation group(n=61)according to random drawing method.The control group was given Oxytocin to prevention and treatment of postpartum hemorrhage,and the observation group was given Misoprostol combined with Calcium to prevention and treatment of postpartum hemorrhage.Postpartum hemorrhage condition,coagulation index,hemodynamic index,inflammatory factors before and after treatment,prevention and treatment effect and adverse reactions were compared between the two groups.Result:The bleeding volume of the observation group at 2 h,12 h and 24 h postpartum was less than that of the control group,the differences were statistically significant(P<0.05).After 12 h of administration,fibrinogen(FIB)increased in both groups,prothrombin time(PT)and thrombin time(TT)decreased,FIB was higher in the observation group,and PT and TT were lower than the control group,the differences were statistically significant(P<0.05).After 12 h of administration,the resistance index(RI)and pulsatility index(PI)decreased in both groups,and the RI and PI of the observation group were lower than that of the control group,the differences were statistically significant(P<0.05).After 12 h of administration,the levels of interleukin-6(IL-6),hypersensitive C response protein(hs-CRP),and tumor necrosis factor-α(TNF-α)were reduced in both groups,and the levels of IL-6,hs-CRP,and TNF-αwere lower than the observation group,the differences were statistically significant(P<0.05).The total response rate in the observation group was higher than the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions between the two groups was not significant(P>0.05).Conclusion:The use of Misoprostol combined with Calcium has a significant effect on the prevention and treatment of postpartum hemorrhage in pregnant women,which can effectively reduce the risk of postpartum hemorrhage,reduce the level of inflammatory factors in the body,and promote patients to return to normal physiological function as soon as possible.