不同椎弓根螺钉内固定治疗脊柱骨折患者的效果

Effect of Different Pedicle Screw Fixation on Patients with Spinal Fracture

目的:观察不同椎弓根螺钉内固定治疗脊柱骨折患者的效果。方法:选取2020年2月—2023年4月泉州市泉港区医院收治的80例脊柱骨折患者为研究对象,将其随机分为对照组(n=40)和研究组(n=40)。对照组予以开放式内固定术,研究组予以Sextant微创内固定术。比较两组临床疗效、手术相关指标、脊柱生理指标、炎症指标水平、氧化应激指标水平、功能障碍及疼痛程度情况。结果:研究组治疗有效率高于对照组,差异有统计学意义(P<0.05);研究组手术切口长度、术中出血量及引流量少于对照组,手术和住院时间短于对照组,差异有统计学意义(P<0.05);手术治疗后,两组Cobb’s角、椎体矢状面指数以及椎体前缘高度明显改善,且研究组改善情况优于对照组,差异有统计学意义(P<0.05);手术治疗后1周,两组白介素-6(IL-6)、C-反应蛋白(CRP)表达水平明显降低,谷胱甘肽过氧化物酶(GSH-Px)和高级氧化蛋白产物(AOPP)表达水平明显升高,且研究组IL-6、CRP水平低于对照组,GSH-Px和AOPP水平高于对照组,差异有统计学意义(P<0.05);手术治疗后3个月,两组ODI和视觉模拟评分量表(VAS)评分明显降低,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:与采用开放式内固定术治疗相比,Sextant微创内固定术的治疗效果更为显著,该种术式可缩短手术时间,控制炎症和氧化应激指标,减轻术后疼痛,可促进患者加速康复。

Objective:To observe the effect of different pedicle screw fixation on patients with spinal fracture.Method:A total of 80 patients with spinal fracture admitted to Quangang District Hospital in Quanzhou City from February 2020 to April 2023 were selected as the subjects and randomly assigned to the control group(n=40)and the study group(n=40).The control group was given open internal fixation,and the study group was given Sextant minimally invasive internal fixation.The clinical efficacy,surgery related indexes,spinal physiological indexes,inflammation indexes,oxidative stress indexes,dysfunction and pain degree were compared between the two groups.Result:The effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The surgical incision length,intraoperative blood loss and drainage volume in the study group were less than those in the control group,and the operation and hospital stay in the study group were shorter than those in the control group,with statistical significance(P<0.05).After surgical treatment,Cobb's Angle,sagittal plane index of vertebral body and anterior margin height of vertebral body were significantly improved in both groups,and the improvement in the study group was better than that in the control group(P<0.05).One week after surgical treatment,the expression levels of interleukin 6(IL-6)and C-reactive protein(CRP)in both groups were significantly decreased.The expression level of glutathione peroxidase(GSH-Px)and advanced oxidized protein products(AOPP)was significantly increased,and IL-6 and CRP levels in research group were lower than those in control group,while GSH-Px and AOPP levels were higher than those in control group.The difference was statistically significant(P<0.05).3 months after surgery,ODI and VAS scores of the two groups were significantly decreased,and the study group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with open internal fixation,Sextant minimally invasive internal fixation has a more significant therapeutic effect,which can shorten the operation time,control inflammation and oxidative stress indexes,reduce postoperative pain,and accelerate the recovery of patients.