丙泊酚导致围手术期神经认知障碍机制的研究进展

Research Progress on the Mechanism of Perioperative Neurocognitive Impairment Caused by Propofol

在手术患者较为常见的麻醉后并发症中,围手术期神经认知障碍的发病率较高,对患者术后的生活质量造成直接影响,目前为止围手术期神经认知障碍的发病原因及其机制还尚未统一明确。其中,丙泊酚是手术患者常用的麻醉药物,已有诸多研究显示,丙泊酚会导致患者围手术期神经认知障碍的发生。本文整合诸多专家学者的研究和临床医护人员的实践数据,对丙泊酚导致围手术期神经认知障碍的相关机制展开探讨,形成综述,以供参考。

Among the more common post-anesthesia complications in surgical patients,the incidence of perioperative neurocognitive impairment is high,which has a direct impact on the postoperative quality of life of patients.So far,the cause and mechanism of perioperative neurocognitive impairment have not been unified and clear.Among them,propofol is a commonly used anesthetic drug for surgical patients,and many studies have shown that propofol can cause perioperative neurocognitive disorders in patients.This article integrates the research of many experts and scholars and the practice data of clinical medical staff,discusses the related mechanism of perioperative neurocognitive impairment caused by propofol,and forms a review for reference.