苍术中聚炔类化学成分及其药理作用研究进展

Research progress on chemical components and pharmacological effects of polyalkynes in Atractylodis rhizoma

苍术为菊科苍术属多年生草本植物,主要分为北苍术和茅苍术,具有健脾、燥湿、明目等功效,在临床上主要用于治疗脾虚湿盛、夜盲症、眼疲劳等症状,根据临床作用以及现代药理研究证实,中药材苍术中含有多种有效成分,如挥发油类、烯炔类、苷类等,而近几年关于苍术的药理研究发现,聚炔类成分中的苍术素在抗炎、治疗细菌耐药性以及抑制胆管癌细胞迁移等方面均具有良好活性,且其较高的生物活性可能与所含的共轭烯炔结构有关。因此通过对近年来已发表的苍术中聚炔类化学成分及其药理作用研究进行总结,全面阐述苍术中聚炔类成分的研究进展,为科研从业者提供参考,以促进对苍术药用价值的深入开发和利用。

Atractylodis rhizoma is a perennial herb of the Asteraceae family,which mainly divided into A.chinensis(DC)Koidz and Atractyiodes lancea(Thunb)DC,with the effects of strengthening the spleen,drying dampness,brightening the eyes,etc.Atractylodis rhizoma is mainly used in the clinical treatment of spleen deficiency and dampness,night blindness,eye fatigue and other symptoms.According to the clinical effect,and modern pharmacological researches have confirmed,the Chinese herbal medicine Atractylodis rhizoma contains a variety of active ingredients,such as volatile oils,alkynes,glycosides,etc.In recent years,pharmacological studies on Atractylodis rhizoma have found that atractylodin in polyalkynes has good activity in anti-inflammation,treatment of bacterial resistance,and inhibition of cholangiocarcinoma cell migration,and its high biological activity may be related to the conjugated enyne structure.Therefore,this article summarizes the studies on chemical components and pharmacological effects of polyalkynes in Atractylodis rhizoma that have been published in recent years,and comprehensively expounds the research progress of polyalkynes in Atractylodis rhizoma,so as to provide reference for scientific researchers and promote the in-depth development and utilization of the medicinal value of Atractylodis rhizoma.