HE4、CA125及CA153在卵巢良性肿瘤诊断中的临床应用价值分析

Analysis of clinical value of HE4,CA125 and CA153 in the diagnosis of benign ovarian tumors

目的 研究血清人附睾蛋白4(HE4)、糖类抗原125(CA125)及糖类抗原153(CA153)在卵巢良性肿瘤诊断中的临床应用价值。方法 选取41例卵巢良性肿瘤患者作为研究对象,将其按照病理检查结果的差异分为子宫内膜异位症组(n=18)及其他卵巢良性肿瘤组(n=23)。检测并对比两组血清HE4、CA125、CA153水平。以受试者工作特征曲线(ROC曲线)分析血清HE4、CA125、CA153水平诊断子宫内膜异位症的效能。对比两组患者手术前后血清HE4、CA125、CA153水平。以Pearson相关性分析明确子宫内膜异位症患者血清HE4、CA125、CA153三项指标间的相关性。结果 子宫内膜异位症组血清HE4、CA125、CA153水平分别为(115.10±12.73)pmol/L、(46.71±6.29)U/ml、(28.58±4.60)U/ml,均高于其他卵巢良性肿瘤组的(86.97±10.30)pmol/L、(38.63±4.80)U/ml、(16.83±3.01)U/ml(P<0.05)。经ROC曲线分析证实,血清HE4、CA125、CA153联合诊断子宫内膜异位症的灵敏度、约登指数、曲线下面积均优于HE4、CA125、CA153单独诊断。子宫内膜异位症组及其他卵巢良性肿瘤组患者术后血清HE4、CA125、CA153水平均低于术前(P<0.05)。经Pearson相关性分析证实,子宫内膜异位症患者血清HE4与CA125、HE4与CA153、CA125与CA153均呈正相关(r=0.735、0.766、0.801, P<0.05)。结论血清HE4、CA125、CA153应用于卵巢良性肿瘤诊断中的价值较高,有利于子宫内膜异位症与其他卵巢良性肿瘤的鉴别诊断,且在评估疗效方面可能存在一定价值。

Objective To study the clinical value of serum human epididymal protein 4(HE4),carbohydrate antigen 125(CA125)and carbohydrate antigen 153(CA153)in the diagnosis of benign ovarian tumors.Methods A total of 41 patients with benign ovarian tumors were selected as the study subjects.They were divided into endometriosis group(n=18)and other benign ovarian tumors group(n=23)according to the difference of pathological examination results.Serum levels of HE4,CA125 and CA153 were detected and compared between the two groups.The efficacy of serum HE4,CA125 and CA153 levels in the diagnosis of endometriosis was analyzed by receiver operating characteristic(ROC)curve.The serum levels of HE4,CA125 and CA153 were compared between the two groups before and after surgery.Pearson correlation analysis was used to determine the correlation of serum HE4,CA125 and CA153 levels in patients with endometriosis.Results The serum levels of HE4,CA125 and CA153 in endometriosis group were(115.10±12.73)pmol/L,(46.71±6.29)U/ml and(28.58±4.60)U/ml,which were higher than(86.97±10.30)pmol/L,(38.63±4.80)U/ml and(16.83±3.01)U/ml of other benign ovarian tumors group(P<0.05).ROC curve analysis confirmed that the sensitivity,Youden's index,and area under the curve of combined diagnosis of serum HE4,CA125 and CA153 levels was better than that of the above three indicators alone.The serum levels of HE4,CA125 and CA153 in endometriosis group and other benign ovarian tumor groups were lower after surgery were lower than those before surgery(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum HE4 and CA125,HE4 and CA153,and CA125 and CA153 in patients with endometriosis(r=0.735,0.766,0.801;P<0.05).Conclusion Serum HE4,CA125 and CA153 levels are of high value in the diagnosis of benign ovarian tumors,which is conducive to the differential diagnosis of endometriosis and other benign ovarian tumors,and may have certain value in evaluating the efficacy.