白头翁汤治疗溃疡性结肠炎的信号通路机制分析

Mechanism of Baitouweng Decoction in alleviating ulcerative colitis via signaling pathways

溃疡性结肠炎(UC)是一种反复发作的炎症性肠病。目前研究认为,其发病与肠道上皮屏障缺陷、肠道菌群失调、免疫应答失调及遗传等因素密切相关。白头翁汤治疗UC具有一定的疗效。白头翁汤及其加减方可通过多种信号通路减少促炎细胞因子的表达,增加机体抗炎因子,促进肠上皮细胞增殖以加速肠上皮修复,保护肠道黏液屏障,减轻肠道炎症反应,从而减少肠上皮细胞异常增殖,避免“炎-癌”的发生。

Ulcerative colitis(UC)is a recurrent inflammatory bowel disease.Current research suggests that its pathogenesis is closely related to factors such as intestinal epithelial barrier defects,gut microbiota dysbiosis,immune response disorders,and genetics.Baitouweng Decoction has shown certain efficacy in treating UC.Baitouweng Decoction and its modified formulas can reduce the expression of pro-inflammatory cytokines through multiple signaling pathways,increase anti-inflammatory factors,promote the proliferation of intestinal epithelial cells to accelerate epithelial repair,protect the intestinal mucosal barrier,and alleviate intestinal inflammation.In this way,they reduce abnormal proliferation of intestinal epithelial cells and prevent the occurrence of inflammation-induced cancer.