火针疗法治疗常见病的效应机制研究进展

Mechanism of fire needle therapy for common diseases:a review

火针疗法适应证广泛,效应机制复杂,其治疗常见病的机制研究主要集中于皮肤疾病、肌肉骨骼系统疾病和神经系统疾病领域,体现出多层次、多靶点、多途径和多环节的特点,其主要效应机制包括:①抗炎与调节免疫;②调控细胞增殖、分化和凋亡;③调节内分泌;④改善血液循环,修复血管;⑤调节神经递质和神经肽;⑥抑制氧化应激反应;⑦修复皮损;⑧保护神经。今后应在临床机制研究中提高方法学质量和报告质量,研发标准化火针针具,制定针对不同疾病的标准治疗方案,重点探索火针疗法的温热性传导机制,并对比火针在不同条件下产生的治疗效应,客观评价火针的安全性,借助多样化的医学成像技术揭示火针疗法的外周和中枢效应机制,并通过系统生物学组学技术整体、动态地阐释火针疗法的综合治疗作用。

Fire needle therapy has a wide range of indications and complex mechanisms.The research on its treatment of common diseases mainly focuses on skin,musculoskeletal system,and neurological disorders,reflecting multi-level,multi-target,multi-pathway,and multi-link characteristics.The primary mechanisms include①anti-inflammatory and immunoregulatory effects;②regulation of cell proliferation,differentiation,and apoptosis;③endocrine modulation;④improvement of blood circulation and vascular repair;⑤regulation of neurotransmitters and neuropeptides;⑥inhibition of oxidative stress;⑦repair of skin lesions;⑧nerve protection.Future research should aim to improve methodological and reporting quality in clinical mechanism studies,develop standardized fire needle instruments,and develop standard treatment protocols for different diseases.It is crucial to explore the thermal conduction mechanism of fire needle therapy,compare its therapeutic effects under various conditions,objectively evaluate its safety,uncover its peripheral and central mechanisms by virtue of diverse medical imaging technologies,and provide a comprehensive and dynamic explanation of the overall effects by omics technologies from systems biology.