铁死亡通路在类风湿关节炎中的研究进展

Research progress of ferroptosis pathway in rheumatoid arthritis

类风湿关节炎(RA)是一种常见的以滑膜炎为病理基础,侵蚀性关节炎为主要症状的慢性自身免疫性疾病。RA的发病机制较为复杂,遗传因素、环境因素、免疫细胞、细胞因子、自身抗体等共同作用引起RA关节损伤、骨破坏及多系统疾病。然而,以上机制并不能完全解释RA预后较差、致残率高、临床治疗效果欠佳等问题。因此,探究RA发病的新机制和治疗靶点是RA研究工作的重点。近年来,随着对RA研究的不断深入,发现RA的病理过程中存在一种新型细胞死亡形式,即铁死亡。铁死亡是一种由多种原因引起谷胱甘肽过氧化物酶活性受抑制,导致脂质活性氧堆积后造成的细胞死亡方式。既往研究已证实RA与铁死亡之间密切相关,而本文主要从调控铁死亡的主要信号通路角度出发,探索影响RA疾病变化发展的铁死亡相关信号通路,以期为RA寻找新的治疗靶点,为研究提供新的治疗思路。

Rheumatoid arthritis(RA)is a common chronic autoimmune disease with synovitis as its pathological basis and erosive arthritis as its main symptom.Pathogenesis of RA is complex,combination of genetic factors,environmental factors,immune cells,cytokines and autoantibodies causes joint injury,bone destruction and multi-system disease of RA.However,the above mecha⁃nisms can not fully explain the poor prognosis,high disability rate and poor clinical treatment effect of RA.Therefore,exploring new pathogenesis and therapeutic targets of RA is the focus of RA research.In recent years,with the deepening of RA research,it has been found that there is a new form of cell death in pathological process of RA,namely ferroptosis.Ferroptosis is a type of cell death caused by inhibition of glutathione peroxidase activity and accumulation of lipid reactive oxygen species.Previous studies have con⁃firmed the close correlation between RA and ferroptosis,this paper mainly explores ferroptosis-related signal pathways that affect the change and development of RA disease from the perspective of regulating the main signal pathways of ferroptosis,so as to find new therapeutic targets for RA and new therapeutic ideas for research.