基于数据挖掘分析曹志群教授治疗腹泻型肠易激综合征的用药规律

Analysis of Medication Rule of Professor Cao Zhiqun in the Treatment of Diarrheal Irritable Bowel Syndrome Based on Data Mining

目的探讨曹志群教授治疗腹泻型肠易激综合征(IBS-D)的用药规律。方法选取2020年10月—2021年10月期间曹志群教授于山东中医药大学附属医院门诊诊治的IBS-D患者128例,选取其首诊处方作为研究对象,使用Microsoft Office Excel 2019软件对中药频率、功效、性味归经等进行频数统计,提取使用频率>30%的高频药物,将数据录入古今医案云平台进行药物关联分析和聚类分析,并使用IBM SPSS Modeler18.0软件对高频药物绘制药物关联网络图。结果128首中药处方中共包含107味中药。其中高频药物有白术、党参、木香、黄连、菟丝子、茯苓、乌梅、莲子、白扁豆等;药性以平性、温性为主,药味以甘、苦、辛为主,归经以脾、胃经为主;系统聚类分析得到新处方4首。结论曹志群教授在治疗IBS-D时围绕着“脾虚湿盛”的基本病机,从肝、脾、肾三脏入手,以疏肝、建中、温下、行气为基本治法,重视健脾化湿,同时注意调节气机升降。

Objective:To study the medication rule of Professor Cao Zhiqun in the treatment of diarrheal irritable bowel syndrome(IBS-D).Methods:A total of 128 IBS-D patients treated by Professor Cao Zhiqun in the outpatient department of The Affiliated Hospital of Shandong University of Chinese Medicine from October 2020 to October 2021 were selected,and their first prescription was selected as the research object.Microsoft Office Excel 2019 software was used to make statistics on the frequency,efficacy,property,taste and channel tropism of herbs.The high-frequency herbs with a frequency of>30%was extracted and the data was input into the cloud platform of Ancient and Modern Medical Records for herb association analysis and cluster analysis.The herb association network diagram for high frequency herbs was drawn by IBM SPSS Model 18.0 software.Results:107 herbs were contained in 128 TCM prescriptions.Among them,the high frequency herbs were atractylodis,codonopsis,costustoot,coptis,dodder,poria,dark plum,lotus seed,white lentil and so on.The properties were mainly mild and warm,the tastes were mainly sweet,bitter and pungent,and the channel tropism was mainly spleen and stomach.Four new prescriptions were obtained by systematic cluster analysis.Conclusion:In the treatment of IBS-D,Professor Cao Zhiqun focused on the basic pathogenesis of"spleen deficiency and excessive dampness",started from the three viscus of liver,spleen and kidney,and took soothing the liver,restoring the spleen and stomach,warming the stomach and intestine and promoting the circulation of qi as the basic treatment methods,paying attention to strengthening the spleen and reducing dampness,and at the same time paying attention to regulating the rise and fall of qi movement.